Layer 6 Cortico-thalamic Pyramidal Cells Preferentially Innervate Interneurons and Generate Facilitating EPSPs Export

@article{citeulike:462370, abstract = {The properties of the connections made by the axons of pyramidal cells with cortico-thalamic (CT)-like morphology with a range of postsynaptic layer 6 targets were studied with dual intracellular recordings in slices of adult rat and cat neocortex. The cells were filled with biocytin and identified morphologically and, where appropriate, immunofluorescently. CT-like pyramids contacted interneurons with a very high probability (up to 1:2) but contacted other layer 6 pyramidal cells only rarely ([\~{}]1:80). The excitatory postsynaptic potentials (EPSPs) that they elicited both in pyramidal cells and in a variety of types of interneurons (including those immunopositive for parvalbumin and for somatostatin) facilitated, the second EPSP being larger than the first over a range of interspike intervals. Facilitation was not, however, maximal at the shortest intervals; in fact, depression was apparent at some connections at short interspike intervals. Facilitation in the majority of connections peaked at intervals of 25-35 ms and then declined slowly. Nor did these connections display the augmentation typical of many other strongly facilitating connections. Third EPSPs were smaller on average than second EPSPs, and fourth and subsequent EPSPs could be depressed (relative to first EPSPs). The properties of the outputs of these CT-like pyramidal cells are therefore quite distinct from those of other pyramidal cells, both within layer 6 and in other layers, possibly reflecting their unique role as both first order thalamo-cortical recipient and cortico-thalamic output neurons. 10.1093/cercor/bhi098}, author = {West, David C. and Mercer, Audrey and Kirchhecker, Sarah and Morris, Oliver T. and Thomson, Alex M.}, citeulike-article-id = {462370}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/cercor/bhi098}, citeulike-linkout-1 = {http://cercor.oxfordjournals.org/content/16/2/200.abstract}, citeulike-linkout-2 = {http://cercor.oxfordjournals.org/content/16/2/200.full.pdf}, citeulike-linkout-3 = {http://www.ingentaconnect.com/content/oup/cercor/2006/00000016/00000002/art00200}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/15843627}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=15843627}, day = {1}, doi = {10.1093/cercor/bhi098}, issn = {1047-3211}, journal = {Cereb. Cortex}, keywords = {cat, cortex, cortico\_thalamic, facilitation, interneuron, l6, pyramidal, rat, thalamus}, month = {February}, number = {2}, pages = {200--211}, posted-at = {2009-11-14 01:02:57}, priority = {2}, publisher = {Oxford University Press}, title = {Layer 6 Cortico-thalamic Pyramidal Cells Preferentially Innervate Interneurons and Generate Facilitating EPSPs}, url = {http://dx.doi.org/10.1093/cercor/bhi098}, volume = {16}, year = {2006} }

TY - JOUR ID - citeulike:462370 L3 - citeulike-article-id:462370 N2 - The properties of the connections made by the axons of pyramidal cells with cortico-thalamic (CT)-like morphology with a range of postsynaptic layer 6 targets were studied with dual intracellular recordings in slices of adult rat and cat neocortex. The cells were filled with biocytin and identified morphologically and, where appropriate, immunofluorescently. CT-like pyramids contacted interneurons with a very high probability (up to 1:2) but contacted other layer 6 pyramidal cells only rarely ([~]1:80). The excitatory postsynaptic potentials (EPSPs) that they elicited both in pyramidal cells and in a variety of types of interneurons (including those immunopositive for parvalbumin and for somatostatin) facilitated, the second EPSP being larger than the first over a range of interspike intervals. Facilitation was not, however, maximal at the shortest intervals; in fact, depression was apparent at some connections at short interspike intervals. Facilitation in the majority of connections peaked at intervals of 25-35 ms and then declined slowly. Nor did these connections display the augmentation typical of many other strongly facilitating connections. Third EPSPs were smaller on average than second EPSPs, and fourth and subsequent EPSPs could be depressed (relative to first EPSPs). The properties of the outputs of these CT-like pyramidal cells are therefore quite distinct from those of other pyramidal cells, both within layer 6 and in other layers, possibly reflecting their unique role as both first order thalamo-cortical recipient and cortico-thalamic output neurons. 10.1093/cercor/bhi098 IS - 2 JF - Cereb. Cortex SN - 1047-3211 EP - 211 TI - Layer 6 Cortico-thalamic Pyramidal Cells Preferentially Innervate Interneurons and Generate Facilitating EPSPs PB - Oxford University Press VL - 16 SP - 200 KW - cat KW - cortex KW - cortico_thalamic KW - facilitation KW - interneuron KW - l6 KW - pyramidal KW - rat KW - thalamus AU - West, David AU - Mercer, Audrey AU - Kirchhecker, Sarah AU - Morris, Oliver AU - Thomson, Alex PY - 2006/02/01/ UR - http://dx.doi.org/10.1093/cercor/bhi098 ER -