Target-cell-specific facilitation and depression in neocortical circuits Export

@article{citeulike:6086701, abstract = {In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortical layer 2/3. We induced repetitive action potentials in pyramidal cells and recorded the evoked unitary excitatory (E)PSPs in two classes of GABAergic neurons. We observed facilitation of EPSPs in bitufted GABAergic interneurons, many of which expressed somatostatin immunoreactivity. EPSPs recorded from multipolar interneurons, however, showed depression. Some of these neurons were immunopositive for parvalbumin. Unitary inhibitory (I)PSPs evoked by repetitive stimulation of a bitufted neuron also showed a less pronounced but significant difference between the two target neurons. Facilitation and depression involve presynaptic mechanisms, and because a single neuron can express both behaviors simultaneously, we infer that local differences in the molecular structure of presynaptic nerve terminals are induced by retrograde signals from different classes of target neurons. Because bitufted and multipolar neurons both formed reciprocal inhibitory connections with pyramidal cells, the results imply that the balance of activation between two recurrent inhibitory pathways in the neocortex depends on the frequency of action potentials in pyramidal cells.}, author = {Reyes, Alex and Lujan, R. and Rozov, A. and Burnashev, N. and Somogyi, P. and Sakmann, B.}, citeulike-article-id = {6086701}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/1092}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn0898_279}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/10195160}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=10195160}, day = {01}, doi = {10.1038/1092}, issn = {1097-6256}, journal = {Nature Neuroscience}, keywords = {cortex, l2, l3, neocortex, pairs, plasticity}, month = {August}, number = {4}, pages = {279--285}, posted-at = {2009-11-10 02:57:29}, priority = {2}, publisher = {Nature Publishing Group}, title = {Target-cell-specific facilitation and depression in neocortical circuits }, url = {http://dx.doi.org/10.1038/1092}, volume = {1}, year = {1998} }

TY - JOUR ID - citeulike:6086701 L3 - citeulike-article-id:6086701 N2 - In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortical layer 2/3. We induced repetitive action potentials in pyramidal cells and recorded the evoked unitary excitatory (E)PSPs in two classes of GABAergic neurons. We observed facilitation of EPSPs in bitufted GABAergic interneurons, many of which expressed somatostatin immunoreactivity. EPSPs recorded from multipolar interneurons, however, showed depression. Some of these neurons were immunopositive for parvalbumin. Unitary inhibitory (I)PSPs evoked by repetitive stimulation of a bitufted neuron also showed a less pronounced but significant difference between the two target neurons. Facilitation and depression involve presynaptic mechanisms, and because a single neuron can express both behaviors simultaneously, we infer that local differences in the molecular structure of presynaptic nerve terminals are induced by retrograde signals from different classes of target neurons. Because bitufted and multipolar neurons both formed reciprocal inhibitory connections with pyramidal cells, the results imply that the balance of activation between two recurrent inhibitory pathways in the neocortex depends on the frequency of action potentials in pyramidal cells. IS - 4 JF - Nature Neuroscience SN - 1097-6256 EP - 285 TI - Target-cell-specific facilitation and depression in neocortical circuits PB - Nature Publishing Group VL - 1 SP - 279 KW - cortex KW - l2 KW - l3 KW - neocortex KW - pairs KW - plasticity AU - Reyes, Alex AU - Lujan, R AU - Rozov, A AU - Burnashev, N AU - Somogyi, P AU - Sakmann, B PY - 1998/08/01/ UR - http://dx.doi.org/10.1038/1092 ER -