Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. Export

@article{citeulike:3151713, abstract = {Recombinant activated factor VII (rFVIIa) is a novel hemostatic agent, originally developed for the treatment of hemorrhage in hemophiliacs with inhibitors, which has been successfully used recently in an increasing number of nonhemophilic bleeding conditions. In the present systematic review we report the existing literature data on the use of this hemostatic agent in severe bleeding, unresponsive to standard treatment, associated with disseminated intravascular coagulation. A total of 99 disseminated intravascular coagulation-associated bleeding episodes treated with rFVIIa were collected from 27 published articles: in the majority of the cases, the underlying disorder complicated by disseminated intravascular coagulation was a postpartum hemorrhage, while in the remaining cases it was a cancer, trauma, sepsis or liver failure. Although limited, the data available suggest that rFVIIa could have a potential role in this clinical setting. Large randomized trials are needed, however, to confirm the preliminary results and to assess the safety and dosing regimens of this agent in refractory bleeding associated with disseminated intravascular coagulation.}, address = {Immunohematology and Transfusion Center, City Hospital of Verona, Italy. mfranchini@univr.it}, author = {Franchini, M. and Manzato, F. and Salvagno, G. L. and Lippi, G.}, citeulike-article-id = {3151713}, citeulike-linkout-0 = {http://dx.doi.org/10.1097/MBC.0b013e32822d2a3c}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17890943}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17890943}, doi = {10.1097/MBC.0b013e32822d2a3c}, issn = {0957-5235}, journal = {Blood coagulation \& fibrinolysis : an international journal in haemostasis and thrombosis}, keywords = {dic, factor7}, month = {October}, number = {7}, pages = {589--593}, posted-at = {2008-08-24 01:33:15}, priority = {2}, title = {Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review.}, url = {http://dx.doi.org/10.1097/MBC.0b013e32822d2a3c}, volume = {18}, year = {2007} }

TY - JOUR ID - citeulike:3151713 L3 - citeulike-article-id:3151713 N2 - Recombinant activated factor VII (rFVIIa) is a novel hemostatic agent, originally developed for the treatment of hemorrhage in hemophiliacs with inhibitors, which has been successfully used recently in an increasing number of nonhemophilic bleeding conditions. In the present systematic review we report the existing literature data on the use of this hemostatic agent in severe bleeding, unresponsive to standard treatment, associated with disseminated intravascular coagulation. A total of 99 disseminated intravascular coagulation-associated bleeding episodes treated with rFVIIa were collected from 27 published articles: in the majority of the cases, the underlying disorder complicated by disseminated intravascular coagulation was a postpartum hemorrhage, while in the remaining cases it was a cancer, trauma, sepsis or liver failure. Although limited, the data available suggest that rFVIIa could have a potential role in this clinical setting. Large randomized trials are needed, however, to confirm the preliminary results and to assess the safety and dosing regimens of this agent in refractory bleeding associated with disseminated intravascular coagulation. IS - 7 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis SN - 0957-5235 AD - Immunohematology and Transfusion Center, City Hospital of Verona, Italy. mfranchini@univr.it EP - 593 TI - Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. VL - 18 SP - 589 KW - dic KW - factor7 AU - Franchini, M AU - Manzato, F AU - Salvagno, GL AU - Lippi, G PY - 2007/10// UR - http://dx.doi.org/10.1097/MBC.0b013e32822d2a3c ER -