In this study Chlorella ellipsoidea was used as food for Daphnia magna in order to investigate the food effect on the toxicity. The effect was found to vary depending on the toxicant used, on the concentration of the toxicant in the water, and on the duration of the exposure. We conducted acute mortality tests with a duration of 1-4 days. Cadmium and chromium were used as toxicants. The toxicity increase due to the presence of food was more prominent for Cr than for Cd.We also investigated the interaction effect of the two heavy metals on Daphnia in the absence of food. That effect was found to be either additive or antagonistic depending on the concentrations used. There were more cases of addition than antagonism.Finally we checked the toxicant content in the body of Daphnia after two days of exposure. It was found that the increased bioaccumulation lead to the death of the animals. The bioaccumulation experiments gave us data to support assumptions concerning the food effect and the interaction effect. © 1993 John Wiley & Sons, Inc.