Universal physical responses to stretch in the living cell Export

@article{citeulike:1353586, abstract = {With every beat of the heart, inflation of the lung or peristalsis of the gut, cell types of diverse function are subjected to substantial stretch. Stretch is a potent stimulus for growth, differentiation, migration, remodelling and gene expression1, 2. Here, we report that in response to transient stretch the cytoskeleton fluidizes in such a way as to define a universal response class. This finding implicates mechanisms mediated not only by specific signalling intermediates, as is usually assumed, but also by non-specific actions of a slowly evolving network of physical forces. These results support the idea that the cell interior is at once a crowded chemical space3 and a fragile soft material in which the effects of biochemistry, molecular crowding and physical forces are complex and inseparable, yet conspire nonetheless to yield remarkably simple phenomenological laws. These laws seem to be both universal and primitive, and thus comprise a striking intersection between the worlds of cell biology and soft matter physics.}, author = {Trepat, Xavier and Deng, Linhong and An, Steven S. and Navajas, Daniel and Tschumperlin, Daniel J. and Gerthoffer, William T. and Butler, James P. and Fredberg, Jeffrey J.}, citeulike-article-id = {1353586}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature05824}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature05824}, day = {31}, doi = {10.1038/nature05824}, issn = {0028-0836}, journal = {Nature}, keywords = {biology, cell, experiment, physics}, month = {May}, number = {7144}, pages = {592--595}, posted-at = {2007-06-01 09:53:02}, priority = {2}, publisher = {Nature Publishing Group}, title = {Universal physical responses to stretch in the living cell}, url = {http://dx.doi.org/10.1038/nature05824}, volume = {447}, year = {2007} }

TY - JOUR ID - citeulike:1353586 L3 - citeulike-article-id:1353586 N2 - With every beat of the heart, inflation of the lung or peristalsis of the gut, cell types of diverse function are subjected to substantial stretch. Stretch is a potent stimulus for growth, differentiation, migration, remodelling and gene expression1, 2. Here, we report that in response to transient stretch the cytoskeleton fluidizes in such a way as to define a universal response class. This finding implicates mechanisms mediated not only by specific signalling intermediates, as is usually assumed, but also by non-specific actions of a slowly evolving network of physical forces. These results support the idea that the cell interior is at once a crowded chemical space3 and a fragile soft material in which the effects of biochemistry, molecular crowding and physical forces are complex and inseparable, yet conspire nonetheless to yield remarkably simple phenomenological laws. These laws seem to be both universal and primitive, and thus comprise a striking intersection between the worlds of cell biology and soft matter physics. IS - 7144 JF - Nature SN - 0028-0836 EP - 595 TI - Universal physical responses to stretch in the living cell PB - Nature Publishing Group VL - 447 SP - 592 KW - biology KW - cell KW - experiment KW - physics AU - Trepat, Xavier AU - Deng, Linhong AU - An, Steven AU - Navajas, Daniel AU - Tschumperlin, Daniel AU - Gerthoffer, William AU - Butler, James AU - Fredberg, Jeffrey PY - 2007/05/31/ UR - http://dx.doi.org/10.1038/nature05824 ER -