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Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin Export

Nature, Vol. 451, No. 7176. (17 January 2008), pp. 363-367.

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aaa modeling xray-crystal-structure

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遺伝性痙性対麻痺で変異が最も高頻度にみられる遺伝子座がコードするタンパク質スパスチン(spastin)、およびカタニン(katanin)は近縁の微小管切断AAA ATPアーゼであり、神経や中心体非関連の微小管配列の形成および染色体の分離に関与する。 ショウジョウバエのスパスチンAAAドメインのX線結晶構造を報告し、X線小角散乱と原子ドッキング法とを組み合わせて、活性化スパスチン6量体形成のモデルを提案する。

cactus (public note) - 2008-02-12 07:02:09

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