Protein folding in confined and crowded environments Export

@article{citeulike:2679554, abstract = {Confinement and crowding are two major factors that can potentially impact protein folding in cellular environments. Theories based on considerations of excluded volumes predict disparate effects on protein folding stability for confinement and crowding: confinement can stabilize proteins by over 10kBT but crowding has a very modest effect on stability. On the other hand, confinement and crowding are both predicted to favor conformations of the unfolded state which are compact, and consequently may increase the folding rate. These predictions are largely borne out by experimental studies of protein folding under confined and crowded conditions in the test tube. Protein folding in cellular environments is further complicated by interactions with surrounding surfaces and other factors. Concerted theoretical modeling and test-tube and in vivo experiments promise to elucidate the complexity of protein folding in cellular environments.}, author = {Zhou, Huan-Xiang}, booktitle = {Highlight Issue: Protein Folding}, citeulike-article-id = {2679554}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.abb.2007.07.013}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S000398610700358X}, citeulike-linkout-2 = {http://www.sciencedirect.com/science/article/B6WB5-4PB0PRV-2/1/d7cd0aa64a1f525cc9fe67957172f5a4}, day = {1}, doi = {10.1016/j.abb.2007.07.013}, journal = {Archives of Biochemistry and Biophysics}, keywords = {confinement, crowding, review}, month = {January}, number = {1}, pages = {76--82}, posted-at = {2008-10-07 10:22:35}, priority = {2}, title = {Protein folding in confined and crowded environments}, url = {http://dx.doi.org/10.1016/j.abb.2007.07.013}, volume = {469}, year = {2008} }

TY - JOUR ID - citeulike:2679554 L3 - citeulike-article-id:2679554 N2 - Confinement and crowding are two major factors that can potentially impact protein folding in cellular environments. Theories based on considerations of excluded volumes predict disparate effects on protein folding stability for confinement and crowding: confinement can stabilize proteins by over 10kBT but crowding has a very modest effect on stability. On the other hand, confinement and crowding are both predicted to favor conformations of the unfolded state which are compact, and consequently may increase the folding rate. These predictions are largely borne out by experimental studies of protein folding under confined and crowded conditions in the test tube. Protein folding in cellular environments is further complicated by interactions with surrounding surfaces and other factors. Concerted theoretical modeling and test-tube and in vivo experiments promise to elucidate the complexity of protein folding in cellular environments. IS - 1 JF - Archives of Biochemistry and Biophysics EP - 82 TI - Protein folding in confined and crowded environments VL - 469 T2 - Highlight Issue: Protein Folding SP - 76 KW - confinement KW - crowding KW - review AU - Zhou, Huan-Xiang PY - 2008/01/01/ UR - http://dx.doi.org/10.1016/j.abb.2007.07.013 ER -