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Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution Export

Nature, Vol. 458, No. 7237., pp. 475-480.

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complex protein rna splicing xray-crystal-structure

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Human spliceosomal U1 small nuclear ribonucleoprotein particles (snRNPs), which consist of U1 small nuclear RNA and ten proteins, recognize the 52 splice site within precursor messenger RNAs and initiate the assembly of the spliceosome for intron excision. An electron density map of the functional core


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