Ribosomal Translocation: One Step Closer to the Molecular Mechanism. Export

@article{citeulike:4082147, abstract = {Protein synthesis occurs in ribosomes, the targets of numerous antibiotics. How these large and complex machines read and move along mRNA have proven to be challenging questions. In this Review, we focus on translocation, the last step of the elongation cycle in which movement of tRNA and mRNA is catalyzed by elongation factor G. Translocation entails large-scale movements of the tRNAs and conformational changes in the ribosome that require numerous tertiary contacts to be disrupted and reformed. We highlight recent progress toward elucidating the molecular basis of translocation and how various antibiotics influence tRNA-mRNA movement.}, author = {Shoji, Shinichiro and Walker, Sarah E. and Fredrick, Kurt}, citeulike-article-id = {4082147}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/cb8002946}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/cb8002946}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19173642}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19173642}, day = {27}, doi = {10.1021/cb8002946}, issn = {1554-8937}, journal = {ACS chemical biology}, keywords = {review, ribosome}, month = {January}, number = {2}, pages = {93--107}, posted-at = {2009-11-12 10:33:00}, priority = {0}, title = {Ribosomal Translocation: One Step Closer to the Molecular Mechanism.}, url = {http://dx.doi.org/10.1021/cb8002946}, volume = {4}, year = {2009} }

TY - JOUR ID - citeulike:4082147 L3 - citeulike-article-id:4082147 N2 - Protein synthesis occurs in ribosomes, the targets of numerous antibiotics. How these large and complex machines read and move along mRNA have proven to be challenging questions. In this Review, we focus on translocation, the last step of the elongation cycle in which movement of tRNA and mRNA is catalyzed by elongation factor G. Translocation entails large-scale movements of the tRNAs and conformational changes in the ribosome that require numerous tertiary contacts to be disrupted and reformed. We highlight recent progress toward elucidating the molecular basis of translocation and how various antibiotics influence tRNA-mRNA movement. IS - 2 JF - ACS chemical biology SN - 1554-8937 EP - 107 TI - Ribosomal Translocation: One Step Closer to the Molecular Mechanism. VL - 4 SP - 93 KW - review KW - ribosome AU - Shoji, Shinichiro AU - Walker, Sarah AU - Fredrick, Kurt PY - 2009/01/27/ UR - http://dx.doi.org/10.1021/cb8002946 ER -