Genetic basis of human brain evolution. Export

@article{citeulike:3410361, abstract = {Human evolution is characterized by a rapid increase in brain size and complexity. Decades of research have made important strides in identifying anatomical and physiological substrates underlying the unique features of the human brain. By contrast, it has become possible only very recently to examine the genetic basis of human brain evolution. Through comparative genomics, tantalizing insights regarding human brain evolution have emerged. The genetic changes that potentially underlie human brain evolution span a wide range from single-nucleotide substitutions to large-scale structural alterations of the genome. Similarly, the functional consequences of these genetic changes vary greatly, including protein-sequence alterations, cis-regulatory changes and even the emergence of new genes and the extinction of existing ones. Here, we provide a general review of recent findings into the genetic basis of human brain evolution, highlight the most notable trends that have emerged and caution against over-interpretation of current data.}, author = {Vallender, Eric J J. and Mekel-Bobrov, Nitzan and Lahn, Bruce T T.}, citeulike-article-id = {3410361}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tins.2008.08.010}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0166223608002099}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18848363}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18848363}, day = {8}, doi = {10.1016/j.tins.2008.08.010}, issn = {0166-2236}, journal = {Trends in neurosciences}, keywords = {awesome}, month = {October}, posted-at = {2009-02-18 17:29:43}, priority = {2}, title = {Genetic basis of human brain evolution.}, url = {http://dx.doi.org/10.1016/j.tins.2008.08.010}, year = {2008} }

TY - JOUR ID - citeulike:3410361 L3 - citeulike-article-id:3410361 N2 - Human evolution is characterized by a rapid increase in brain size and complexity. Decades of research have made important strides in identifying anatomical and physiological substrates underlying the unique features of the human brain. By contrast, it has become possible only very recently to examine the genetic basis of human brain evolution. Through comparative genomics, tantalizing insights regarding human brain evolution have emerged. The genetic changes that potentially underlie human brain evolution span a wide range from single-nucleotide substitutions to large-scale structural alterations of the genome. Similarly, the functional consequences of these genetic changes vary greatly, including protein-sequence alterations, cis-regulatory changes and even the emergence of new genes and the extinction of existing ones. Here, we provide a general review of recent findings into the genetic basis of human brain evolution, highlight the most notable trends that have emerged and caution against over-interpretation of current data. JF - Trends in neurosciences SN - 0166-2236 TI - Genetic basis of human brain evolution. KW - awesome AU - Vallender, Eric J AU - Mekel-Bobrov, Nitzan AU - Lahn, Bruce T PY - 2008/10/08/ UR - http://dx.doi.org/10.1016/j.tins.2008.08.010 ER -