The SOS response controls integron recombination Export

@article{667, abstract = {Integrons are found in the genome of hundreds of environmental bacteria but are mainly known for their role in the capture and spread of antibiotic resistance determinants among Gram-negative pathogens. We report a direct link between this system and the ubiquitous SOS response. We found that LexA controlled expression of most integron integrases and consequently regulated cassette recombination. This regulatory coupling enhanced the potential for cassette swapping and capture in cells under stress, while minimizing cassette rearrangements or loss in constant environments. This finding exposes integrons as integrated adaptive systems and has implications for antibiotic treatment policies.}, address = {Universite de Limoges, Faculte de Medecine, EA3175, INSERM, Equipe Avenir, 87000 Limoges, France.}, author = {Guerin, E. and Cambray, G. and Sanchez-Alberola, N. and Campoy, S. and Erill, I. and Da Re, S. and Gonzalez-Zorn, B. and Barbe, J. and Ploy, M. C. and Mazel, D.}, citeulike-article-id = {5769647}, citeulike-linkout-0 = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19460999}, journal = {Science}, keywords = {binding, expression, promoter, recombination, regulation, resistance, serine, sos, vibrio}, number = {5930}, pages = {1034+}, posted-at = {2009-09-10 14:15:58}, priority = {2}, title = {The SOS response controls integron recombination}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19460999}, volume = {324} }

TY - JOUR ID - 667 L3 - citeulike-article-id:5769647 N2 - Integrons are found in the genome of hundreds of environmental bacteria but are mainly known for their role in the capture and spread of antibiotic resistance determinants among Gram-negative pathogens. We report a direct link between this system and the ubiquitous SOS response. We found that LexA controlled expression of most integron integrases and consequently regulated cassette recombination. This regulatory coupling enhanced the potential for cassette swapping and capture in cells under stress, while minimizing cassette rearrangements or loss in constant environments. This finding exposes integrons as integrated adaptive systems and has implications for antibiotic treatment policies. IS - 5930 JF - Science AD - Universite de Limoges, Faculte de Medecine, EA3175, INSERM, Equipe Avenir, 87000 Limoges, France. TI - The SOS response controls integron recombination VL - 324 SP - 1034 KW - binding KW - expression KW - promoter KW - recombination KW - regulation KW - resistance KW - serine KW - sos KW - vibrio AU - Guerin, E AU - Cambray, G AU - Sanchez-Alberola, N AU - Campoy, S AU - Erill, I AU - Da Re, S AU - Gonzalez-Zorn, B AU - Barbe, J AU - Ploy, MC AU - Mazel, D UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19460999 ER -