UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes.

by: Jack Zhang, G Tim T Bowden

Molecular carcinogenesis (30 April 2008)

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Abstract

Considerable evidence has demonstrated that UVB irradiation is a strong carcinogen for nonmelanoma skin cancer. Up-regulation of cyclooxygenase -2 (Cox-2) has been shown to be a crucial event in human keratinocytes in their responses to UVB irradiation. To further understand the molecular mechanisms governing Cox-2 regulation, we found that UVB irradiation significantly increased Cox-2 mRNA stability by inducing cytoplasmic localization and protein abundance of human antigen R (HuR). We also found that AMP-activated kinase (AMPK) mediates these events and that UVB reduces AMPK activity by down-regulating LKB1 kinase. Finally, we propose a novel model in which UVB regulates Cox-2 mRNA stability through the LKB1/AMPK pathway. (c) 2008 Wiley-Liss, Inc.

@article{citeulike:2776585, abstract = {Considerable evidence has demonstrated that UVB irradiation is a strong carcinogen for nonmelanoma skin cancer. Up-regulation of cyclooxygenase -2 (Cox-2) has been shown to be a crucial event in human keratinocytes in their responses to UVB irradiation. To further understand the molecular mechanisms governing Cox-2 regulation, we found that UVB irradiation significantly increased Cox-2 mRNA stability by inducing cytoplasmic localization and protein abundance of human antigen R (HuR). We also found that AMP-activated kinase (AMPK) mediates these events and that UVB reduces AMPK activity by down-regulating LKB1 kinase. Finally, we propose a novel model in which UVB regulates Cox-2 mRNA stability through the LKB1/AMPK pathway. (c) 2008 Wiley-Liss, Inc.}, address = {Arizona Cancer Center, Tucson, Arizona.}, author = {Zhang, Jack and Bowden, G Tim T. }, citeulike-article-id = {2776585}, doi = {10.1002/mc.20450}, issn = {1098-2744}, journal = {Molecular carcinogenesis}, keywords = {ampk, keratinocytes}, month = {April}, posted-at = {2008-05-09 21:35:05}, priority = {2}, title = {UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes.}, url = {http://dx.doi.org/10.1002/mc.20450}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2776585 TI - UVB irradiation regulates Cox-2 mRNA stability through AMPK and HuR in human keratinocytes. JF - Molecular carcinogenesis AD - Arizona Cancer Center, Tucson, Arizona. SN - 1098-2744 N2 - Considerable evidence has demonstrated that UVB irradiation is a strong carcinogen for nonmelanoma skin cancer. Up-regulation of cyclooxygenase -2 (Cox-2) has been shown to be a crucial event in human keratinocytes in their responses to UVB irradiation. To further understand the molecular mechanisms governing Cox-2 regulation, we found that UVB irradiation significantly increased Cox-2 mRNA stability by inducing cytoplasmic localization and protein abundance of human antigen R (HuR). We also found that AMP-activated kinase (AMPK) mediates these events and that UVB reduces AMPK activity by down-regulating LKB1 kinase. Finally, we propose a novel model in which UVB regulates Cox-2 mRNA stability through the LKB1/AMPK pathway. (c) 2008 Wiley-Liss, Inc. KW - ampk KW - keratinocytes AU - Zhang, Jack AU - Bowden, G Tim PY - 2008/04/30/ UR - http://dx.doi.org/10.1002/mc.20450 ER -

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