Rates of evolutionary change in viruses: patterns and determinants. Export

@article{citeulike:2562888, abstract = {Understanding the factors that determine the rate at which genomes generate and fix mutations provides important insights into key evolutionary mechanisms. We review our current knowledge of the rates of mutation and substitution, as well as their determinants, in RNA viruses, DNA viruses and retroviruses. We show that the high rate of nucleotide substitution in RNA viruses is matched by some DNA viruses, suggesting that evolutionary rates in viruses are explained by diverse aspects of viral biology, such as genomic architecture and replication speed, and not simply by polymerase fidelity.}, author = {Duffy, Siobain and Shackelton, Laura A. and Holmes, Edward C.}, citeulike-article-id = {2562888}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2323}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2323}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18319742}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18319742}, day = {04}, doi = {10.1038/nrg2323}, issn = {1471-0064}, journal = {Nature reviews. Genetics}, keywords = {evolutionary\_rates, review, rna\_virus}, month = {April}, number = {4}, pages = {267--276}, posted-at = {2009-11-03 03:40:11}, priority = {2}, publisher = {Nature Publishing Group}, title = {Rates of evolutionary change in viruses: patterns and determinants.}, url = {http://dx.doi.org/10.1038/nrg2323}, volume = {9}, year = {2008} }

TY - JOUR ID - citeulike:2562888 L3 - citeulike-article-id:2562888 N2 - Understanding the factors that determine the rate at which genomes generate and fix mutations provides important insights into key evolutionary mechanisms. We review our current knowledge of the rates of mutation and substitution, as well as their determinants, in RNA viruses, DNA viruses and retroviruses. We show that the high rate of nucleotide substitution in RNA viruses is matched by some DNA viruses, suggesting that evolutionary rates in viruses are explained by diverse aspects of viral biology, such as genomic architecture and replication speed, and not simply by polymerase fidelity. IS - 4 JF - Nature reviews. Genetics SN - 1471-0064 EP - 276 TI - Rates of evolutionary change in viruses: patterns and determinants. PB - Nature Publishing Group VL - 9 SP - 267 KW - evolutionary_rates KW - review KW - rna_virus AU - Duffy, Siobain AU - Shackelton, Laura AU - Holmes, Edward PY - 2008/04/04/ UR - http://dx.doi.org/10.1038/nrg2323 ER -