Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Export

@article{citeulike:3313952, abstract = {A reduction in the cellular levels of the cyclin kinase inhibitor p27(kip1) is frequently found in many human cancers and correlates directly with patient prognosis. In this work, we identify argyrin A, a cyclical peptide derived from the myxobacterium Archangium gephyra, as a potent antitumoral drug. All antitumoral activities of argyrin A depend on the prevention of p27(kip1) destruction, as loss of p27(kip1) expression confers resistance to this compound. We find that argyrin A exerts its effects through a potent inhibition of the proteasome. By comparing the cellular responses exerted by argyrin A with siRNA-mediated knockdown of proteasomal subunits, we find that the biological effects of proteasome inhibition per se depend on the expression of p27(kip1).}, address = {Institute for Molecular Biology, Hannover Medical School, 30625 Hannover, Germany.}, author = {Nickeleit, I. and Zender, S. and Sasse, F. and Geffers, R. and Brandes, G. and S\"{o}rensen, I. and Steinmetz, H. and Kubicka, S. and Carlomagno, T. and Menche, D. and G\"{u}tgemann, I. and Buer, J. and Gossler, A. and Manns, M. P. and Kalesse, M. and Frank, R. and Malek, N. P.}, citeulike-article-id = {3313952}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ccr.2008.05.016}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18598941}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18598941}, day = {8}, doi = {10.1016/j.ccr.2008.05.016}, issn = {1535-6108}, journal = {Cancer cell}, keywords = {apoptosis, argyrin, cancer, degradation, p27, proteasome}, month = {July}, number = {1}, pages = {23--35}, posted-at = {2008-09-22 11:17:22}, priority = {2}, title = {Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition.}, url = {http://dx.doi.org/10.1016/j.ccr.2008.05.016}, volume = {14}, year = {2008} }

TY - JOUR ID - citeulike:3313952 L3 - citeulike-article-id:3313952 N2 - A reduction in the cellular levels of the cyclin kinase inhibitor p27(kip1) is frequently found in many human cancers and correlates directly with patient prognosis. In this work, we identify argyrin A, a cyclical peptide derived from the myxobacterium Archangium gephyra, as a potent antitumoral drug. All antitumoral activities of argyrin A depend on the prevention of p27(kip1) destruction, as loss of p27(kip1) expression confers resistance to this compound. We find that argyrin A exerts its effects through a potent inhibition of the proteasome. By comparing the cellular responses exerted by argyrin A with siRNA-mediated knockdown of proteasomal subunits, we find that the biological effects of proteasome inhibition per se depend on the expression of p27(kip1). IS - 1 JF - Cancer cell SN - 1535-6108 AD - Institute for Molecular Biology, Hannover Medical School, 30625 Hannover, Germany. EP - 35 TI - Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. VL - 14 SP - 23 KW - apoptosis KW - argyrin KW - cancer KW - degradation KW - p27 KW - proteasome AU - Nickeleit, I AU - Zender, S AU - Sasse, F AU - Geffers, R AU - Brandes, G AU - Sörensen, I AU - Steinmetz, H AU - Kubicka, S AU - Carlomagno, T AU - Menche, D AU - Gütgemann, I AU - Buer, J AU - Gossler, A AU - Manns, MP AU - Kalesse, M AU - Frank, R AU - Malek, NP PY - 2008/07/08/ UR - http://dx.doi.org/10.1016/j.ccr.2008.05.016 ER -