Extracellular matrix regulation of autophagy. Export

@article{citeulike:3761588, abstract = {Integrin-mediated attachment of epithelial cells to extracellular matrix (ECM) is crucial for proper growth and survival. Although detachment leads to apoptosis, termed anoikis, recent work demonstrates that ECM detachment also robustly induces autophagy, a tightly regulated lysosomal self-digestion process that actually promotes survival. Autophagy presumably protects epithelial cells from the stresses of ECM detachment, allowing them to survive provided that they reattach in a timely manner. Currently, the intracellular signals linking integrin engagement to autophagy remain unclear, but certain growth factor, energy-sensing, and stress-response pathways represent attractive candidates. Moreover, autophagy may be a previously unrecognized mechanism utilized by detached cancer cells to survive anoikis, which may facilitate tumor cell dormancy, dissemination, and metastasis.}, author = {Lock, Rebecca and Debnath, Jayanta}, citeulike-article-id = {3761588}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ceb.2008.05.002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18573652}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18573652}, doi = {10.1016/j.ceb.2008.05.002}, issn = {0955-0674}, journal = {Current opinion in cell biology}, keywords = {anchorage, autophagy, detachment, ecm, integrin}, month = {October}, number = {5}, pages = {583--588}, posted-at = {2008-12-09 17:47:10}, priority = {2}, title = {Extracellular matrix regulation of autophagy.}, url = {http://dx.doi.org/10.1016/j.ceb.2008.05.002}, volume = {20}, year = {2008} }

TY - JOUR ID - citeulike:3761588 L3 - citeulike-article-id:3761588 N2 - Integrin-mediated attachment of epithelial cells to extracellular matrix (ECM) is crucial for proper growth and survival. Although detachment leads to apoptosis, termed anoikis, recent work demonstrates that ECM detachment also robustly induces autophagy, a tightly regulated lysosomal self-digestion process that actually promotes survival. Autophagy presumably protects epithelial cells from the stresses of ECM detachment, allowing them to survive provided that they reattach in a timely manner. Currently, the intracellular signals linking integrin engagement to autophagy remain unclear, but certain growth factor, energy-sensing, and stress-response pathways represent attractive candidates. Moreover, autophagy may be a previously unrecognized mechanism utilized by detached cancer cells to survive anoikis, which may facilitate tumor cell dormancy, dissemination, and metastasis. IS - 5 JF - Current opinion in cell biology SN - 0955-0674 EP - 588 TI - Extracellular matrix regulation of autophagy. VL - 20 SP - 583 KW - anchorage KW - autophagy KW - detachment KW - ecm KW - integrin AU - Lock, Rebecca AU - Debnath, Jayanta PY - 2008/10// UR - http://dx.doi.org/10.1016/j.ceb.2008.05.002 ER -