Cyclin A is required at two points in the human cell cycle.

@article{citeulike:3846979, abstract = {Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The human cyclin A gene was identified as the site of integration of hepatitis B virus in a hepatocarcinoma cell line; in addition, cyclin A is associated with the E2F transcription factor in a complex which is dissociated by the E1A oncogene product. Such findings suggest that cyclin A is a target for oncogenic signals. We have now found that DNA synthesis and entry into mitosis are inhibited in human cells microinjected with anti-cyclin A antibodies at distinct times. Cyclin A binds both cdk2 and cdc2, giving two distinct cyclin A kinase activities, one appearing in S phase, the other in G2. These results suggest that cyclin A defines novel control points of the human cell cycle.}, author = {Pagano, M. and Pepperkok, R. and Verde, F. and Ansorge, W. and Draetta, G.}, citeulike-article-id = {3846979}, issn = {0261-4189}, journal = {The EMBO journal}, keywords = {cellcycle, cyclina}, month = {March}, number = {3}, pages = {961--971}, posted-at = {2009-01-04 13:08:19}, priority = {2}, title = {Cyclin A is required at two points in the human cell cycle.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1312467}, volume = {11}, year = {1992} }

TY - JOUR ID - citeulike:3846979 L3 - citeulike-article-id:3846979 N2 - Cyclins play a fundamental role in regulating cell cycle events in all eukaryotic cells. The human cyclin A gene was identified as the site of integration of hepatitis B virus in a hepatocarcinoma cell line; in addition, cyclin A is associated with the E2F transcription factor in a complex which is dissociated by the E1A oncogene product. Such findings suggest that cyclin A is a target for oncogenic signals. We have now found that DNA synthesis and entry into mitosis are inhibited in human cells microinjected with anti-cyclin A antibodies at distinct times. Cyclin A binds both cdk2 and cdc2, giving two distinct cyclin A kinase activities, one appearing in S phase, the other in G2. These results suggest that cyclin A defines novel control points of the human cell cycle. IS - 3 JF - The EMBO journal SN - 0261-4189 EP - 971 TI - Cyclin A is required at two points in the human cell cycle. VL - 11 SP - 961 KW - cellcycle KW - cyclina AU - Pagano, M AU - Pepperkok, R AU - Verde, F AU - Ansorge, W AU - Draetta, G PY - 1992/03// UR - http://view.ncbi.nlm.nih.gov/pubmed/1312467 ER -