Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Export

@article{citeulike:3871070, abstract = {In human neuroblastoma, amplification of the MYCN gene predicts poor prognosis and resistance to therapy. In a shRNA screen of genes that are highly expressed in MYCN-amplified tumors, we have identified AURKA as a gene that is required for the growth of MYCN-amplified neuroblastoma cells but largely dispensable for cells lacking amplified MYCN. Aurora A has a critical function in regulating turnover of the N-Myc protein. Degradation of N-Myc requires sequential phosphorylation by cyclin B/Cdk1 and Gsk3. N-Myc is therefore degraded during mitosis in response to low levels of PI3-kinase activity. Aurora A interacts with both N-Myc and the SCF(Fbxw7) ubiquitin ligase that ubiquitinates N-Myc and counteracts degradation of N-Myc, thereby uncoupling N-Myc stability from growth factor-dependent signals.}, author = {Otto, T. and Horn, S. and Brockmann, M. and Eilers, U. and Sch\"{u}ttrumpf, L. and Popov, N. and Kenney, A. M. and Schulte, J. H. and Beijersbergen, R. and Christiansen, H. and Berwanger, B. and Eilers, M.}, citeulike-article-id = {3871070}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ccr.2008.12.005}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19111882}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19111882}, day = {6}, doi = {10.1016/j.ccr.2008.12.005}, issn = {1535-6108}, journal = {Cancer cell}, keywords = {aurora, auroraa, myc, neuroblastoma}, month = {January}, number = {1}, pages = {67--78}, posted-at = {2009-02-13 15:13:54}, priority = {2}, title = {Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma.}, url = {http://dx.doi.org/10.1016/j.ccr.2008.12.005}, volume = {15}, year = {2009} }

TY - JOUR ID - citeulike:3871070 L3 - citeulike-article-id:3871070 N2 - In human neuroblastoma, amplification of the MYCN gene predicts poor prognosis and resistance to therapy. In a shRNA screen of genes that are highly expressed in MYCN-amplified tumors, we have identified AURKA as a gene that is required for the growth of MYCN-amplified neuroblastoma cells but largely dispensable for cells lacking amplified MYCN. Aurora A has a critical function in regulating turnover of the N-Myc protein. Degradation of N-Myc requires sequential phosphorylation by cyclin B/Cdk1 and Gsk3. N-Myc is therefore degraded during mitosis in response to low levels of PI3-kinase activity. Aurora A interacts with both N-Myc and the SCF(Fbxw7) ubiquitin ligase that ubiquitinates N-Myc and counteracts degradation of N-Myc, thereby uncoupling N-Myc stability from growth factor-dependent signals. IS - 1 JF - Cancer cell SN - 1535-6108 EP - 78 TI - Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. VL - 15 SP - 67 KW - aurora KW - auroraa KW - myc KW - neuroblastoma AU - Otto, T AU - Horn, S AU - Brockmann, M AU - Eilers, U AU - Schüttrumpf, L AU - Popov, N AU - Kenney, AM AU - Schulte, JH AU - Beijersbergen, R AU - Christiansen, H AU - Berwanger, B AU - Eilers, M PY - 2009/01/06/ UR - http://dx.doi.org/10.1016/j.ccr.2008.12.005 ER -