Control of radiation-induced G1 arrest by cell-substratum interactions. Export

@article{citeulike:4116255, abstract = {Ionizing radiation has been reported to cause an irreversible, senescence-like G1 arrest in human fibroblasts, which is accompanied by elevated p21CIP1 amounts. In further support of a senescence-like arrest, we show that expression of p53 and cyclin D1 is elevated in gamma-irradiated, arrested fibroblasts. However, we also demonstrate that the arrest is reversible if the irradiated cells are trypsinized and replated, which may implicate cellular-extracellular matrix interactions in cell cycle control after irradiation.}, author = {Gadbois, D. M. and Bradbury, E. M. and Lehnert, B. E.}, citeulike-article-id = {4116255}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9067286}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9067286}, day = {15}, issn = {0008-5472}, journal = {Cancer research}, keywords = {adhesion, arrest, damage, dna, p53}, month = {March}, number = {6}, pages = {1151--1156}, posted-at = {2009-03-01 12:12:25}, priority = {2}, title = {Control of radiation-induced G1 arrest by cell-substratum interactions.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9067286}, volume = {57}, year = {1997} }

TY - JOUR ID - citeulike:4116255 L3 - citeulike-article-id:4116255 N2 - Ionizing radiation has been reported to cause an irreversible, senescence-like G1 arrest in human fibroblasts, which is accompanied by elevated p21CIP1 amounts. In further support of a senescence-like arrest, we show that expression of p53 and cyclin D1 is elevated in gamma-irradiated, arrested fibroblasts. However, we also demonstrate that the arrest is reversible if the irradiated cells are trypsinized and replated, which may implicate cellular-extracellular matrix interactions in cell cycle control after irradiation. IS - 6 JF - Cancer research SN - 0008-5472 EP - 1156 TI - Control of radiation-induced G1 arrest by cell-substratum interactions. VL - 57 SP - 1151 KW - adhesion KW - arrest KW - damage KW - dna KW - p53 AU - Gadbois, DM AU - Bradbury, EM AU - Lehnert, BE PY - 1997/03/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9067286 ER -