An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63 Export

@article{citeulike:4129721, abstract = {Double-strand breaks in DNA activate the kinases ATM and ATR, which block entry into mitosis. ATM and ATR also delay mitotic progression by controlling spindle assembly in Xenopus egg extracts through the phosphorylation of the centrosomal protein CEP63, leading to its delocalization from the centrosome.}, author = {Smith, Eloise and Dejsuphong, Donniphat and Balestrini, Alessia and Hampel, Martin and Lenz, Christof and Takeda, Shunichi and Vindigni, Alessandro and Costanzo, Vincenzo}, citeulike-article-id = {4129721}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ncb1835}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ncb1835}, day = {01}, doi = {10.1038/ncb1835}, issn = {1465-7392}, journal = {Nature Cell Biology}, keywords = {atm, atr, cep63, damage, dna, spindle}, month = {February}, number = {3}, pages = {278--285}, posted-at = {2009-03-18 14:21:08}, priority = {2}, publisher = {Nature Publishing Group}, title = {An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63}, url = {http://dx.doi.org/10.1038/ncb1835}, volume = {11}, year = {2009} }

TY - JOUR ID - citeulike:4129721 L3 - citeulike-article-id:4129721 N2 - Double-strand breaks in DNA activate the kinases ATM and ATR, which block entry into mitosis. ATM and ATR also delay mitotic progression by controlling spindle assembly in Xenopus egg extracts through the phosphorylation of the centrosomal protein CEP63, leading to its delocalization from the centrosome. IS - 3 JF - Nature Cell Biology SN - 1465-7392 EP - 285 TI - An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63 PB - Nature Publishing Group VL - 11 SP - 278 KW - atm KW - atr KW - cep63 KW - damage KW - dna KW - spindle AU - Smith, Eloise AU - Dejsuphong, Donniphat AU - Balestrini, Alessia AU - Hampel, Martin AU - Lenz, Christof AU - Takeda, Shunichi AU - Vindigni, Alessandro AU - Costanzo, Vincenzo PY - 2009/02/01/ UR - http://dx.doi.org/10.1038/ncb1835 ER -