Artesunate-erythropoietin combination for murine cerebral malaria treatment. Export

@article{citeulike:2746280, abstract = {Cerebral malaria is the most severe and rapidly fatal complication of Plasmodium falciparum infection. Despite appropriate anti-malarial treatment using quinine or artemisinin derivatives, 10-20\% of mortality still occurs during the acute phase. To improve cerebral malaria outcome, adjunctive therapies are clearly needed. Most experiments in this area have been dedicated to immuno-modulation with various successes. Since erythropoietin has been shown to be highly effective in human ischemic stroke and in murine cerebral malaria, we addressed the issue of cerebral malaria outcome improvement by erythropoietin-artesunate drug combination. Compared to the previous study using erythropoietin high doses at the early beginning of the disease, erythropoietin treatment was decreased by six-fold and delayed to the pre-mortem phase. We studied effects on survival and on clinical recovery of the drug combination given from day 6 to day 8 post-infection to CBA/J mice infected by Plasmodium berghei ANKA. We showed that the artesunate-erythropoietin drug combination led to clinical recovery 24h earlier for surviving mice, and to increase in the global survival rate compared to artesunate monotherapy (p<0.01). Since erythropoietin has no effect on parasite clearance, it could be stated that this drug combination is efficient and that erythropoietin could be a lead for the implementation of a new adjunctive therapy during the acute phase of cerebral malaria.}, address = {University Lyon 1, EA 4170, Parasitology \& Tropical Medicine, Faculty of Medicine, 8 avenue Rockefeller, 69373 Lyon cedex 08, France.}, author = {Bienvenu, Anne-Lise L. and Ferrandiz, Josette and Kaiser, Karine and Latour, Christine and Picot, St\'{e}phane}, citeulike-article-id = {2746280}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.actatropica.2008.02.001}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18359468}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18359468}, day = {15}, doi = {10.1016/j.actatropica.2008.02.001}, issn = {0001-706X}, journal = {Acta tropica}, keywords = {cerebral, malaria}, month = {February}, posted-at = {2008-05-02 18:03:04}, priority = {2}, title = {Artesunate-erythropoietin combination for murine cerebral malaria treatment.}, url = {http://dx.doi.org/10.1016/j.actatropica.2008.02.001}, year = {2008} }

TY - JOUR ID - citeulike:2746280 L3 - citeulike-article-id:2746280 N2 - Cerebral malaria is the most severe and rapidly fatal complication of Plasmodium falciparum infection. Despite appropriate anti-malarial treatment using quinine or artemisinin derivatives, 10-20% of mortality still occurs during the acute phase. To improve cerebral malaria outcome, adjunctive therapies are clearly needed. Most experiments in this area have been dedicated to immuno-modulation with various successes. Since erythropoietin has been shown to be highly effective in human ischemic stroke and in murine cerebral malaria, we addressed the issue of cerebral malaria outcome improvement by erythropoietin-artesunate drug combination. Compared to the previous study using erythropoietin high doses at the early beginning of the disease, erythropoietin treatment was decreased by six-fold and delayed to the pre-mortem phase. We studied effects on survival and on clinical recovery of the drug combination given from day 6 to day 8 post-infection to CBA/J mice infected by Plasmodium berghei ANKA. We showed that the artesunate-erythropoietin drug combination led to clinical recovery 24h earlier for surviving mice, and to increase in the global survival rate compared to artesunate monotherapy (p<0.01). Since erythropoietin has no effect on parasite clearance, it could be stated that this drug combination is efficient and that erythropoietin could be a lead for the implementation of a new adjunctive therapy during the acute phase of cerebral malaria. JF - Acta tropica SN - 0001-706X AD - University Lyon 1, EA 4170, Parasitology & Tropical Medicine, Faculty of Medicine, 8 avenue Rockefeller, 69373 Lyon cedex 08, France. TI - Artesunate-erythropoietin combination for murine cerebral malaria treatment. KW - cerebral KW - malaria AU - Bienvenu, Anne-Lise AU - Ferrandiz, Josette AU - Kaiser, Karine AU - Latour, Christine AU - Picot, Stéphane PY - 2008/02/15/ UR - http://dx.doi.org/10.1016/j.actatropica.2008.02.001 ER -