Up-regulated HIF-1alpha is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning. Export

@article{citeulike:2942382, abstract = {Hyperbaric oxygen preconditioning (HBO-PC) has been shown to be effective in preventing hypoxic injuries in many animal models. The aim of the present study was to examine the hypoxic tolerance induced by HBO-PC and to explore the role of hypoxia-inducible factor-1alpha (HIF-1alpha) in a global hypoxia model. Male mice received HBO-PC before hypoxia exposure and swimming. HBO-PC significantly prolonged the survival time and the tolerance time of swimming under normobaric hypoxia. HBO-PC increased the protein content of HIF-1alpha and erythropoietin (EPO) in the cerebral cortex and hippocampus and prevented the changes of blood brain barrier (BBB) permeability and brain edema caused by hypoxia exposure. The results suggested that HBO-PC induced hypoxic tolerance in mice via up-regulation of HIF-1alpha and its downstream genes.}, address = {Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, PR China.}, author = {Peng, Z. and Ren, P. and Kang, Z. and Du, J. and Lian, Q. and Liu, Y. and Zhang, J. H. and Sun, X.}, citeulike-article-id = {2942382}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.brainres.2008.03.027}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18439571}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18439571}, day = {30}, doi = {10.1016/j.brainres.2008.03.027}, issn = {0006-8993}, journal = {Brain research}, keywords = {alpha, hif-1}, month = {May}, pages = {71--78}, posted-at = {2008-06-29 23:48:45}, priority = {2}, title = {Up-regulated HIF-1alpha is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning.}, url = {http://dx.doi.org/10.1016/j.brainres.2008.03.027}, volume = {1212}, year = {2008} }

TY - JOUR ID - citeulike:2942382 L3 - citeulike-article-id:2942382 N2 - Hyperbaric oxygen preconditioning (HBO-PC) has been shown to be effective in preventing hypoxic injuries in many animal models. The aim of the present study was to examine the hypoxic tolerance induced by HBO-PC and to explore the role of hypoxia-inducible factor-1alpha (HIF-1alpha) in a global hypoxia model. Male mice received HBO-PC before hypoxia exposure and swimming. HBO-PC significantly prolonged the survival time and the tolerance time of swimming under normobaric hypoxia. HBO-PC increased the protein content of HIF-1alpha and erythropoietin (EPO) in the cerebral cortex and hippocampus and prevented the changes of blood brain barrier (BBB) permeability and brain edema caused by hypoxia exposure. The results suggested that HBO-PC induced hypoxic tolerance in mice via up-regulation of HIF-1alpha and its downstream genes. JF - Brain research SN - 0006-8993 AD - Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, PR China. EP - 78 TI - Up-regulated HIF-1alpha is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning. VL - 1212 SP - 71 KW - alpha KW - hif-1 AU - Peng, Z AU - Ren, P AU - Kang, Z AU - Du, J AU - Lian, Q AU - Liu, Y AU - Zhang, JH AU - Sun, X PY - 2008/05/30/ UR - http://dx.doi.org/10.1016/j.brainres.2008.03.027 ER -