Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study. Export

@article{citeulike:3504402, abstract = {Evidence suggests that progesterone enhances functional recovery in rats after medial frontal cortical contusions; however, a high dose of progesterone exacerbates tissue loss in a stroke model when administered chronically (7-10 days) prior to injury [Stroke 31 (2000) 1173)]. This study attempts to determine progesterone's dose-response effects on behavioral performance and GABA-A receptor expression following a cortical contusion. Male rats received injections of 0, 8, 16, or 32 mg/kg progesterone in 22.5\% 2-hydroxypropyl-beta-cyclodextrin following cortical impact. Lesion 8 mg/kg and lesion 16 mg/kg groups displayed less thigmotaxis in the Morris water maze (MWM) than 0 and 32 mg/kg groups and were not significantly impaired relative to shams on other water maze measures. Increased variability in the 32 mg/kg group during somatosensory neglect testing was the only evidence indicating that a high dose of progesterone was disruptive to a few animals. These results suggest that low and moderate doses of progesterone are optimal for facilitating recovery of select behaviors and that postinjury progesterone treatment permits a wider dose range than preinjury treatment. Progesterone did not affect lesion size, but a strong negative correlation was observed between thalamic GABA-A receptor density and water maze performance. Future studies could explore causes for this relationship.}, author = {Goss, C. W. and Hoffman, S. W. and Stein, D. G.}, citeulike-article-id = {3504402}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/14592674}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=14592674}, issn = {0091-3057}, journal = {Pharmacology, biochemistry, and behavior}, month = {September}, number = {2}, pages = {231--242}, posted-at = {2008-11-11 21:22:45}, priority = {2}, title = {Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/14592674}, volume = {76}, year = {2003} }

TY - JOUR ID - citeulike:3504402 L3 - citeulike-article-id:3504402 N2 - Evidence suggests that progesterone enhances functional recovery in rats after medial frontal cortical contusions; however, a high dose of progesterone exacerbates tissue loss in a stroke model when administered chronically (7-10 days) prior to injury [Stroke 31 (2000) 1173)]. This study attempts to determine progesterone's dose-response effects on behavioral performance and GABA-A receptor expression following a cortical contusion. Male rats received injections of 0, 8, 16, or 32 mg/kg progesterone in 22.5% 2-hydroxypropyl-beta-cyclodextrin following cortical impact. Lesion 8 mg/kg and lesion 16 mg/kg groups displayed less thigmotaxis in the Morris water maze (MWM) than 0 and 32 mg/kg groups and were not significantly impaired relative to shams on other water maze measures. Increased variability in the 32 mg/kg group during somatosensory neglect testing was the only evidence indicating that a high dose of progesterone was disruptive to a few animals. These results suggest that low and moderate doses of progesterone are optimal for facilitating recovery of select behaviors and that postinjury progesterone treatment permits a wider dose range than preinjury treatment. Progesterone did not affect lesion size, but a strong negative correlation was observed between thalamic GABA-A receptor density and water maze performance. Future studies could explore causes for this relationship. IS - 2 JF - Pharmacology, biochemistry, and behavior SN - 0091-3057 EP - 242 TI - Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study. VL - 76 SP - 231 AU - Goss, CW AU - Hoffman, SW AU - Stein, DG PY - 2003/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/14592674 ER -