The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. Export

@article{citeulike:3504429, abstract = {This report compares the effects of progesterone and its metabolite, allopregnanolone, on the early injury cascade (apoptosis) and long-term functional deficits after TBI. Progesterone (16 mg/kg) or allopregnanolone (4, 8, or 16 mg/kg) were injected at 1 h, 6 h, and then for 5 consecutive days after bilateral contusions of the frontal cortex in adult male rats. Within one day after injury, progesterone and allopregnanolone reduced both the expression of pro-apoptotic proteins caspase-3 and Bax, and apoptotic DNA fragmentation. Progesterone and allopregnanolone also reduced the size of glial fibrillary acid protein (GFAP)-positive astrocytes at the lesion site 24 h after injury. Compared to sham-operated controls at 19 days after injury, injured rats given either progesterone or any of three doses of allopregnanolone had equivalent numbers of ChAT-positive cells in the nucleus basalis magnocellularis. At 19 days post-injury, rats given progesterone or allopregnanolone (8 mg/kg) showed improved performance in a spatial learning task compared to injured rats given only the vehicle. These results provide evidence of the anti-apoptotic and anti-astrogliotic effects of progesterone and allopregnanolone and help to explain why better cognitive performance is observed after injury when animals are given either neurosteroid.}, author = {Djebaili, M. and Guo, Q. and Pettus, E. H. and Hoffman, S. W. and Stein, D. G.}, citeulike-article-id = {3504429}, citeulike-linkout-0 = {http://dx.doi.org/10.1089/neu.2005.22.106}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15665606}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15665606}, doi = {10.1089/neu.2005.22.106}, issn = {0897-7151}, journal = {Journal of neurotrauma}, month = {January}, number = {1}, pages = {106--118}, posted-at = {2008-11-11 21:37:45}, priority = {2}, title = {The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats.}, url = {http://dx.doi.org/10.1089/neu.2005.22.106}, volume = {22}, year = {2005} }

TY - JOUR ID - citeulike:3504429 L3 - citeulike-article-id:3504429 N2 - This report compares the effects of progesterone and its metabolite, allopregnanolone, on the early injury cascade (apoptosis) and long-term functional deficits after TBI. Progesterone (16 mg/kg) or allopregnanolone (4, 8, or 16 mg/kg) were injected at 1 h, 6 h, and then for 5 consecutive days after bilateral contusions of the frontal cortex in adult male rats. Within one day after injury, progesterone and allopregnanolone reduced both the expression of pro-apoptotic proteins caspase-3 and Bax, and apoptotic DNA fragmentation. Progesterone and allopregnanolone also reduced the size of glial fibrillary acid protein (GFAP)-positive astrocytes at the lesion site 24 h after injury. Compared to sham-operated controls at 19 days after injury, injured rats given either progesterone or any of three doses of allopregnanolone had equivalent numbers of ChAT-positive cells in the nucleus basalis magnocellularis. At 19 days post-injury, rats given progesterone or allopregnanolone (8 mg/kg) showed improved performance in a spatial learning task compared to injured rats given only the vehicle. These results provide evidence of the anti-apoptotic and anti-astrogliotic effects of progesterone and allopregnanolone and help to explain why better cognitive performance is observed after injury when animals are given either neurosteroid. IS - 1 JF - Journal of neurotrauma SN - 0897-7151 EP - 118 TI - The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats. VL - 22 SP - 106 AU - Djebaili, M AU - Guo, Q AU - Pettus, EH AU - Hoffman, SW AU - Stein, DG PY - 2005/01// UR - http://dx.doi.org/10.1089/neu.2005.22.106 ER -