Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19. Export

@article{citeulike:6053935, abstract = {Cerebral malaria (CM) is an acute, generally lethal condition characterized by high fever, seizures and coma. The genetic component to CM can be investigated in mouse models that vary in degree of susceptibility to infection with Plasmodium berghei ANKA. Using survival time to measure susceptibility in an informative F2 cross (n=257), we identified linkage to chromosome 19 (Berr5 (Berghei resistance locus 5), LOD=4.69) controlling, in part, the differential response between resistant BALB/c and susceptible C57BL/6 progenitors. BALB/c alleles convey increased survival through the cerebral phase of infection but have no quantitative effect on parasitemia during the later, anemic phase. The Berr5 locus colocalizes with three other immune loci, including Trl-4 (tuberculosis resistance), Tsiq2 (T-cell secretion of IL-4) and Eae19 (experimental allergic encephalitis 19), suggesting the possibility of a common genetic effect underlying these phenotypes. Potential positional candidates include the family of Ifit1-3 (interferon-inducible protein with tetratricopeptide repeats 1-3) and Fas.Genes and Immunity advance online publication, 29 October 2009; doi:10.1038/gene.2009.79.}, author = {Berghout, J. and Min-Oo, G. and Tam, M. and Gauthier, S. and Stevenson, M. M. and Gros, P.}, citeulike-article-id = {6053935}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/gene.2009.79}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19865103}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19865103}, day = {29}, doi = {10.1038/gene.2009.79}, issn = {1476-5470}, journal = {Genes and immunity}, month = {October}, posted-at = {2009-11-01 20:01:35}, priority = {2}, title = {Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19.}, url = {http://dx.doi.org/10.1038/gene.2009.79}, year = {2009} }

TY - JOUR ID - citeulike:6053935 L3 - citeulike-article-id:6053935 N2 - Cerebral malaria (CM) is an acute, generally lethal condition characterized by high fever, seizures and coma. The genetic component to CM can be investigated in mouse models that vary in degree of susceptibility to infection with Plasmodium berghei ANKA. Using survival time to measure susceptibility in an informative F2 cross (n=257), we identified linkage to chromosome 19 (Berr5 (Berghei resistance locus 5), LOD=4.69) controlling, in part, the differential response between resistant BALB/c and susceptible C57BL/6 progenitors. BALB/c alleles convey increased survival through the cerebral phase of infection but have no quantitative effect on parasitemia during the later, anemic phase. The Berr5 locus colocalizes with three other immune loci, including Trl-4 (tuberculosis resistance), Tsiq2 (T-cell secretion of IL-4) and Eae19 (experimental allergic encephalitis 19), suggesting the possibility of a common genetic effect underlying these phenotypes. Potential positional candidates include the family of Ifit1-3 (interferon-inducible protein with tetratricopeptide repeats 1-3) and Fas.Genes and Immunity advance online publication, 29 October 2009; doi:10.1038/gene.2009.79. JF - Genes and immunity SN - 1476-5470 TI - Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19. AU - Berghout, J AU - Min-Oo, G AU - Tam, M AU - Gauthier, S AU - Stevenson, MM AU - Gros, P PY - 2009/10/29/ UR - http://dx.doi.org/10.1038/gene.2009.79 ER -