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The New England journal of medicine, Vol. 361, No. 5. (30 July 2009), pp. 455-467.
by Arjen M. Dondorp, François Nosten, Poravuth Yi, et al.Debashish Das, Aung Phae P. Phyo, Joel Tarning, Khin Maung M. Lwin, Frederic Ariey, Warunee Hanpithakpong, Sue J. Lee, Pascal Ringwald, Kamolrat Silamut, Mallika Imwong, Kesinee Chotivanich, Pharath Lim, Trent Herdman, Sen Sam S. An, Shunmay Yeung, Pratap Singhasivanon, Nicholas P. Day, Niklas Lindegardh, Duong Socheat, Nicholas J. White
Abstract
BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease. There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance. METHODS: In two open-label, randomized trials, we compared the efficacies of two treatments for uncomplicated falciparum malaria in Pailin, western Cambodia, and Wang Pha, northwestern Thailand: oral artesunate given at a dose of 2 mg per kilogram of body weight ...
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Malaria journal, Vol. 8, No. 1. (2 September 2009), 207.
Abstract
ABSTRACT: BACKGROUND: Mefloquine and artesunate combination therapy is the recommended first-line treatment for uncomplicated malaria throughout much of south-east Asia. Concerns have been raised about the potential central nervous system (CNS) effects of both drug components and there are no detailed reports in very young children. METHODS: Children, aged between three months and five years, with acute uncomplicated Plasmodium falciparum malaria were randomized to either 7 days of artesunate monotherapy or the same schedule of artesunate plus mefloquine on day 7 ...
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Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 97, No. 3. (n 2003), pp. 273-276.
Abstract
Nutritional deficiency and malaria are 2 major causes of anaemia during pregnancy in tropical areas. The relationship between anaemia, its treatment with iron and folate, and malaria was studied in a prospective cohort of 2112 pregnant Karen women on the north-western border of Thailand between 1993 and 1997. The development of Plasmodium vivax malaria was associated with a past mean haematocrit > 30% (hazard ratio = 1.5, 95% CI 1.2-2, P = 0.001) and recent (< or = 30 d) iron ...
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Malaria Journal, Vol. 7, No. 1. (2008)
by Sue Lee, Kasia Stepniewska, Nicholas Anstey, et al.Elizabeth Ashley, Karen Barnes, Tran Q. Binh, Umberto D'Alessandro, Nicholas Day, Peter de Vries, Grant Dorsey, Jean P. Guthmann, Mayfong Mayxay, Paul Newton, Francois Nosten, Piero Olliaro, Lyda Osario, Loretxu Pinoges, Ric Price, Mark Rowland, Frank Smithuis, Robert Taylor, Nicholas White
Abstract
BACKGROUND:Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. METHODS:Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit ...
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The American journal of tropical medicine and hygiene, Vol. 77, No. 3. (September 2007), pp. 447-450.
Abstract
Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical trials, data on cardiotoxicity are limited. In two randomized controlled trials in Thailand, 56 patients had ECGs performed before treatment, 4 hours after the first dose, and 4 hours after the last dose. The mean (95% CI) changes in QTc interval (Bazett's correction) were 2 (-6 to 9) ms and 14 (7 to 21) ms, respectively. These small changes ...
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