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Biochemical and biophysical research communications, Vol. 268, No. 1. (5 February 2000), pp. 133-135, doi:10.1006/bbrc.2000.2098 Key: citeulike:12048435
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A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC(50) = 700 nM) in the series displaying an inhibitory profile which is different from reported inhibitors of beta-amyloid formation. Copyright 2000 Academic Press.
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