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Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.

by: G. Abbenante, D. M. Kovacs, D. L. Leung, D. J. Craik, R. E. Tanzi, D. P. Fairlie
Biochemical and biophysical research communications, Vol. 268, No. 1. (5 February 2000), pp. 133-135, doi:10.1006/bbrc.2000.2098  Key: citeulike:12048435

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Abstract

A series of inhibitors of beta-amyloid formation have been developed based on the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein. A simple tripeptide aldehyde was found to be the most potent (IC(50) = 700 nM) in the series displaying an inhibitory profile which is different from reported inhibitors of beta-amyloid formation. Copyright 2000 Academic Press.


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