Analysis of biomolecule detection with optofluidic ring resonator sensors Export

@article{citeulike:1877794, abstract = {We theoretically and experimentally analyze the biomolecule detection capability of the liquid core optical ring resonator (LCORR) as a label-free bio/chemical sensor. We first establish a simple and general linear relationship between the LCORR's bulk refractive index sensitivity (BRIS) and its response to molecule deposition onto the surface, which enables us to easily characterize the LCORR sensing performance. Then, biosensing experiments are performed with bovine serum albumin (BSA) and LCORRs of various BRISs. The experimental results are in good agreement with the theoretical prediction. Further analysis shows that the LCORR is capable of detecting BSA below 10 pM with sub-picogram/mm2 mass detection limit.}, author = {Zhu, Hongying and White, Ian M. and Suter, Jonathan D. and Dale, Paul S. and Fan, Xudong}, citeulike-article-id = {1877794}, citeulike-linkout-0 = {http://www.opticsinfobase.org/abstract.cfm?id=139697}, day = {23}, journal = {Opt. Express}, keywords = {optofluidic, resonators, sensors}, month = {July}, number = {15}, pages = {9139--9146}, posted-at = {2008-08-28 14:08:46}, priority = {2}, publisher = {OSA}, title = {Analysis of biomolecule detection with optofluidic ring resonator sensors}, url = {http://www.opticsinfobase.org/abstract.cfm?id=139697}, volume = {15}, year = {2007} }

TY - JOUR ID - citeulike:1877794 L3 - citeulike-article-id:1877794 N2 - We theoretically and experimentally analyze the biomolecule detection capability of the liquid core optical ring resonator (LCORR) as a label-free bio/chemical sensor. We first establish a simple and general linear relationship between the LCORR’s bulk refractive index sensitivity (BRIS) and its response to molecule deposition onto the surface, which enables us to easily characterize the LCORR sensing performance. Then, biosensing experiments are performed with bovine serum albumin (BSA) and LCORRs of various BRISs. The experimental results are in good agreement with the theoretical prediction. Further analysis shows that the LCORR is capable of detecting BSA below 10 pM with sub-picogram/mm2 mass detection limit. IS - 15 JF - Opt. Express EP - 9146 TI - Analysis of biomolecule detection with optofluidic ring resonator sensors PB - OSA VL - 15 SP - 9139 KW - optofluidic KW - resonators KW - sensors AU - Zhu, Hongying AU - White, Ian AU - Suter, Jonathan AU - Dale, Paul AU - Fan, Xudong PY - 2007/07/23/ UR - http://www.opticsinfobase.org/abstract.cfm?id=139697 ER -