Macromolecular white matter abnormalities in geriatric depression: a magnetization transfer imaging study. Export

@article{citeulike:3100992, abstract = {OBJECTIVE: Geriatric depression consists of complex and heterogeneous behaviors unlikely to be caused by a single brain lesion. However, abnormalities in specific brain structures and their interconnections may confer vulnerability to the development of late-life depression. The objective of this study was to identify subtle white matter abnormalities in late-life depression. DESIGN: The authors used magnetization transfer ratio (MTR) imaging, a technique that is thought primarily to reflect myelin integrity, to examine the hypothesis that individuals with late-life depression would exhibit white matter abnormalities in frontostriatal and limbic regions. SETTING: The study was conducted in a university-based, geriatric psychiatry clinic. PARTICIPANTS: Fifty-five older patients with major depression and 24 elderly comparison subjects were assessed. MEASUREMENT: Voxel-based analysis of MTR data were conducted with a general linear model using age as a covariate. RESULTS: Relative to comparison subjects, patients demonstrated lower MTR in multiple left hemisphere frontostriatal and limbic regions, including white matter lateral to the lentiform nuclei, dorsolateral and dorsomedial prefrontal, dorsal anterior cingulate, subcallosal, periamygdalar, insular, and posterior cingulate regions. Depressed patients had lower MTR in additional left hemisphere locales including the thalamus, splenium of the corpus callosum, inferior parietal, precuneus, and middle occipital white matter regions. CONCLUSION: These findings suggest that geriatric depression may be characterized by reduced myelin integrity in specific aspects of frontostriatal and limbic networks, and complement diffusion tensor studies of geriatric depression that indicate decreased organization of white matter fibers in specific frontal and temporal regions.}, address = {Institute of Geriatric Psychiatry and the Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA. fgd2002@med.cornell.edu}, author = {Gunning-Dixon, F. M. and Hoptman, M. J. and Lim, K. O. and Murphy, C. F. and Klimstra, S. and Latoussakis, V. and Majcher-Tascio, M. and Hrabe, J. and Ardekani, B. A. and Alexopoulos, G. S.}, citeulike-article-id = {3100992}, citeulike-linkout-0 = {http://dx.doi.org/10.1097/JGP.0b013e3181602a66}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18378551}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18378551}, doi = {10.1097/JGP.0b013e3181602a66}, issn = {1545-7214}, journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry}, keywords = {aged, alexopoulos, depression, mri}, month = {April}, number = {4}, pages = {255--262}, posted-at = {2008-08-08 15:20:41}, priority = {2}, title = {Macromolecular white matter abnormalities in geriatric depression: a magnetization transfer imaging study.}, url = {http://dx.doi.org/10.1097/JGP.0b013e3181602a66}, volume = {16}, year = {2008} }

TY - JOUR ID - citeulike:3100992 L3 - citeulike-article-id:3100992 N2 - OBJECTIVE: Geriatric depression consists of complex and heterogeneous behaviors unlikely to be caused by a single brain lesion. However, abnormalities in specific brain structures and their interconnections may confer vulnerability to the development of late-life depression. The objective of this study was to identify subtle white matter abnormalities in late-life depression. DESIGN: The authors used magnetization transfer ratio (MTR) imaging, a technique that is thought primarily to reflect myelin integrity, to examine the hypothesis that individuals with late-life depression would exhibit white matter abnormalities in frontostriatal and limbic regions. SETTING: The study was conducted in a university-based, geriatric psychiatry clinic. PARTICIPANTS: Fifty-five older patients with major depression and 24 elderly comparison subjects were assessed. MEASUREMENT: Voxel-based analysis of MTR data were conducted with a general linear model using age as a covariate. RESULTS: Relative to comparison subjects, patients demonstrated lower MTR in multiple left hemisphere frontostriatal and limbic regions, including white matter lateral to the lentiform nuclei, dorsolateral and dorsomedial prefrontal, dorsal anterior cingulate, subcallosal, periamygdalar, insular, and posterior cingulate regions. Depressed patients had lower MTR in additional left hemisphere locales including the thalamus, splenium of the corpus callosum, inferior parietal, precuneus, and middle occipital white matter regions. CONCLUSION: These findings suggest that geriatric depression may be characterized by reduced myelin integrity in specific aspects of frontostriatal and limbic networks, and complement diffusion tensor studies of geriatric depression that indicate decreased organization of white matter fibers in specific frontal and temporal regions. IS - 4 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry SN - 1545-7214 AD - Institute of Geriatric Psychiatry and the Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA. fgd2002@med.cornell.edu EP - 262 TI - Macromolecular white matter abnormalities in geriatric depression: a magnetization transfer imaging study. VL - 16 SP - 255 KW - aged KW - alexopoulos KW - depression KW - mri AU - Gunning-Dixon, FM AU - Hoptman, MJ AU - Lim, KO AU - Murphy, CF AU - Klimstra, S AU - Latoussakis, V AU - Majcher-Tascio, M AU - Hrabe, J AU - Ardekani, BA AU - Alexopoulos, GS PY - 2008/04// UR - http://dx.doi.org/10.1097/JGP.0b013e3181602a66 ER -