Electrophysiological evidence for reduced inhibitory control in depressed patients in partial remission: a Go/Nogo study. Export

@article{citeulike:3125236, abstract = {Major depressive disorder (MDD) can be characterized by a wide-ranging profile of cognitive deficits including attention, memory, and executive functions which is possibly due to reduced volumes and a hypometabolism of the anterior cingulate cortex, orbitofrontal, and dorsolateral prefrontal cortex. We examined 21 patients with MDD in partial remission and 21 age-, sex-, and education matched healthy controls using event-related potentials (ERPs). Participants performed a hybrid flanker Go/Nogo task while multichannel EEG was recorded. Two ERP components were of interest which repeatedly have been linked to response inhibition: the Nogo-N2 and the Nogo-P3 which can be observed in Nogo trials of a Go/Nogo task. MDD patients showed a specifically reduced Nogo-P3 while the Nogo-N2 and the P3b in Go trials were unaffected. These results provide further evidence of impaired response monitoring and control processes in patients with MDD.}, address = {Department of Psychiatry, Christophsbad G\"{o}ppingen, Germany. martin.ruchsow@christophsbad.de}, author = {Ruchsow, M. and Groen, G. and Kiefer, M. and Beschoner, P. and Hermle, L. and Ebert, D. and Falkenstein, M.}, citeulike-article-id = {3125236}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ijpsycho.2008.01.010}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18313159}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18313159}, doi = {10.1016/j.ijpsycho.2008.01.010}, issn = {0167-8760}, journal = {International journal of psychophysiology : official journal of the International Organization of Psychophysiology}, keywords = {depression, go-nogo, inhibition, remitted}, month = {June}, number = {3}, pages = {209--218}, posted-at = {2008-08-15 05:01:56}, priority = {2}, title = {Electrophysiological evidence for reduced inhibitory control in depressed patients in partial remission: a Go/Nogo study.}, url = {http://dx.doi.org/10.1016/j.ijpsycho.2008.01.010}, volume = {68}, year = {2008} }

TY - JOUR ID - citeulike:3125236 L3 - citeulike-article-id:3125236 N2 - Major depressive disorder (MDD) can be characterized by a wide-ranging profile of cognitive deficits including attention, memory, and executive functions which is possibly due to reduced volumes and a hypometabolism of the anterior cingulate cortex, orbitofrontal, and dorsolateral prefrontal cortex. We examined 21 patients with MDD in partial remission and 21 age-, sex-, and education matched healthy controls using event-related potentials (ERPs). Participants performed a hybrid flanker Go/Nogo task while multichannel EEG was recorded. Two ERP components were of interest which repeatedly have been linked to response inhibition: the Nogo-N2 and the Nogo-P3 which can be observed in Nogo trials of a Go/Nogo task. MDD patients showed a specifically reduced Nogo-P3 while the Nogo-N2 and the P3b in Go trials were unaffected. These results provide further evidence of impaired response monitoring and control processes in patients with MDD. IS - 3 JF - International journal of psychophysiology : official journal of the International Organization of Psychophysiology SN - 0167-8760 AD - Department of Psychiatry, Christophsbad Göppingen, Germany. martin.ruchsow@christophsbad.de EP - 218 TI - Electrophysiological evidence for reduced inhibitory control in depressed patients in partial remission: a Go/Nogo study. VL - 68 SP - 209 KW - depression KW - go-nogo KW - inhibition KW - remitted AU - Ruchsow, M AU - Groen, G AU - Kiefer, M AU - Beschoner, P AU - Hermle, L AU - Ebert, D AU - Falkenstein, M PY - 2008/06// UR - http://dx.doi.org/10.1016/j.ijpsycho.2008.01.010 ER -