Mismatch negativity to the patient's own name in chronic disorders of consciousness. Export

@article{citeulike:4362492, abstract = {Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (>1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n=4), vegetative state (VS, n=6), and minimally conscious state (MCS, n=2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness.}, author = {Qin, P. and Di, H. and Yan, X. and Yu, S. and Yu, D. and Laureys, S. and Weng, X.}, citeulike-article-id = {4362492}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neulet.2008.10.029}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18938213}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18938213}, day = {19}, doi = {10.1016/j.neulet.2008.10.029}, issn = {0304-3940}, journal = {Neuroscience letters}, keywords = {clinical, erp, mmn}, month = {December}, number = {1}, pages = {24--28}, posted-at = {2009-04-18 12:27:09}, priority = {2}, title = {Mismatch negativity to the patient's own name in chronic disorders of consciousness.}, url = {http://dx.doi.org/10.1016/j.neulet.2008.10.029}, volume = {448}, year = {2008} }

TY - JOUR ID - citeulike:4362492 L3 - citeulike-article-id:4362492 N2 - Previous studies implicated potential value of mismatch negativity (MMN) in predicting recovery of consciousness in patients with disorders of consciousness (DOC). We have adopted a novel MMN evoked by subject's own name (SON), a self-referential stimulus thought to be powerful in evoking residual brain activity, and examined the correlation between the MMN and recovery of consciousness in patients with chronic (>1 month) DOC. Twelve patients and 12 age-matched healthy controls were investigated. The patients were diagnosed as coma (n=4), vegetative state (VS, n=6), and minimally conscious state (MCS, n=2), mainly based on the JFK Coma Recovery Scale-Revised. The SON-evoked MMN (SON-MMN) was present in seven patients. Critically, the presence of SON-MMN was significantly correlated with recovery of consciousness. While four of the five patients (three VS and two coma) showing SON-MMN changed to MCS 3 months later, the rest of the patients (three VS and two coma) without SON-MMN failed to show any clinical improvement. Our study thus illustrates that the subject's own name is effective in evoking MMN in patients with DOC, and that SON-MMN has potential prognostic values in predicting recovery of consciousness. IS - 1 JF - Neuroscience letters SN - 0304-3940 EP - 28 TI - Mismatch negativity to the patient's own name in chronic disorders of consciousness. VL - 448 SP - 24 KW - clinical KW - erp KW - mmn AU - Qin, P AU - Di, H AU - Yan, X AU - Yu, S AU - Yu, D AU - Laureys, S AU - Weng, X PY - 2008/12/19/ UR - http://dx.doi.org/10.1016/j.neulet.2008.10.029 ER -