Sarcoplasmic reticulum: The dynamic calcium governor of muscle Export

@article{citeulike:2906326, abstract = {The sarcoplasmic reticulum (SR) provides feedback control required to balance the processes of calcium storage, release, and reuptake in skeletal muscle. This balance is achieved through the concerted action of three major classes of SR calcium-regulatory proteins: (1) luminal calcium-binding proteins (calsequestrin, histidine-rich calcium-binding protein, junctate, and sarcalumenin) for calcium storage; (2) SR calcium release channels (type 1 ryanodine receptor or RyR1 and IP3 receptors) for calcium release; and (3) sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pumps for calcium reuptake. Proper calcium storage, release, and reuptake are essential for normal skeletal muscle function. We review SR structure and function during normal skeletal muscle activity, the proteins that orchestrate calcium storage, release, and reuptake, and how phenotypically distinct muscle diseases (e.g., malignant hyperthermia, central core disease, and Brody disease) can result from subtle alterations in the activity of several key components of the SR calcium-regulatory machinery. Muscle Nerve, 2006}, address = {Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA}, author = {Rossi, Ann E. and Dirksen, Robert T.}, citeulike-article-id = {2906326}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/mus.20512}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/112413378/ABSTRACT}, doi = {10.1002/mus.20512}, journal = {Muscle \& Nerve}, keywords = {ca-release, ca-uptake, calcium-buffers, calsequestrin, camkii, disease, junctate, junctin, junctophilin, pka, review, sr-ca2, triadin}, number = {6}, pages = {715--731}, posted-at = {2008-06-18 23:59:43}, priority = {5}, title = {Sarcoplasmic reticulum: The dynamic calcium governor of muscle}, url = {http://dx.doi.org/10.1002/mus.20512}, volume = {33}, year = {2006} }

TY - JOUR ID - citeulike:2906326 L3 - citeulike-article-id:2906326 N2 - The sarcoplasmic reticulum (SR) provides feedback control required to balance the processes of calcium storage, release, and reuptake in skeletal muscle. This balance is achieved through the concerted action of three major classes of SR calcium-regulatory proteins: (1) luminal calcium-binding proteins (calsequestrin, histidine-rich calcium-binding protein, junctate, and sarcalumenin) for calcium storage; (2) SR calcium release channels (type 1 ryanodine receptor or RyR1 and IP3 receptors) for calcium release; and (3) sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pumps for calcium reuptake. Proper calcium storage, release, and reuptake are essential for normal skeletal muscle function. We review SR structure and function during normal skeletal muscle activity, the proteins that orchestrate calcium storage, release, and reuptake, and how phenotypically distinct muscle diseases (e.g., malignant hyperthermia, central core disease, and Brody disease) can result from subtle alterations in the activity of several key components of the SR calcium-regulatory machinery. Muscle Nerve, 2006 IS - 6 JF - Muscle & Nerve AD - Department of Pharmacology and Physiology, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA EP - 731 TI - Sarcoplasmic reticulum: The dynamic calcium governor of muscle VL - 33 SP - 715 KW - ca-release KW - ca-uptake KW - calcium-buffers KW - calsequestrin KW - camkii KW - disease KW - junctate KW - junctin KW - junctophilin KW - pka KW - review KW - sr-ca2 KW - triadin AU - Rossi, Ann AU - Dirksen, Robert PY - 2006/// UR - http://dx.doi.org/10.1002/mus.20512 ER -