Ryanodine receptor adaptation: control mechanism of Ca2+ -induced Ca2+ release in heart. Export

@article{citeulike:3011554, abstract = {Abstract: Adaptation of single cardiac ryanodine receptor (RyR) channels was demonstrated by application of the caged calcium ion ([Ca.sup.2+]) methodology. In contrast to conventional desensitization found in surface membrane ligand-gated channels, single cardiac RyR channels adapted to maintained [Ca.sup.2+] stimuli, preserving their ability to respond to a second (larger) [Ca.sup.2+] stimulus. RyR adaptation may represent a molecular control mechanism for smoothly graded [Ca.sup.2+]-induced [Ca.sup.2+] release in heart and may be a fundamental feature of channels, including the inositol trisphosphate receptor, that are involved in intracellular [Ca.sup.2+] signaling in many cell types.}, author = {Gyorke, S. and Fill, M.}, citeulike-article-id = {3011554}, journal = {Scinece}, keywords = {caged-calcium, desensitization, dm-nitrophen, ryr-adaptation, ryr-gating, sr-ca-release}, month = {May}, number = {5109}, pages = {807--809}, posted-at = {2008-07-17 02:13:37}, priority = {5}, title = {Ryanodine receptor adaptation: control mechanism of Ca2+ -induced Ca2+ release in heart.}, volume = {260}, year = {1993} }

TY - JOUR ID - citeulike:3011554 L3 - citeulike-article-id:3011554 N2 - Abstract: Adaptation of single cardiac ryanodine receptor (RyR) channels was demonstrated by application of the caged calcium ion ([Ca.sup.2+]) methodology. In contrast to conventional desensitization found in surface membrane ligand-gated channels, single cardiac RyR channels adapted to maintained [Ca.sup.2+] stimuli, preserving their ability to respond to a second (larger) [Ca.sup.2+] stimulus. RyR adaptation may represent a molecular control mechanism for smoothly graded [Ca.sup.2+]-induced [Ca.sup.2+] release in heart and may be a fundamental feature of channels, including the inositol trisphosphate receptor, that are involved in intracellular [Ca.sup.2+] signaling in many cell types. IS - 5109 JF - Scinece EP - 809 TI - Ryanodine receptor adaptation: control mechanism of Ca2+ -induced Ca2+ release in heart. VL - 260 SP - 807 KW - caged-calcium KW - desensitization KW - dm-nitrophen KW - ryr-adaptation KW - ryr-gating KW - sr-ca-release AU - Gyorke, S AU - Fill, M PY - 1993/05// ER -