Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain Export

@article{citeulike:3343389, abstract = {Neurogenesis occurs continuously in the forebrain of adult mammals, but the functional importance of adult neurogenesis is still unclear. Here, using a genetic labeling method in adult mice, we found that continuous neurogenesis results in the replacement of the majority of granule neurons in the olfactory bulb and a substantial addition of granule neurons to the hippocampal dentate gyrus. Genetic ablation of newly formed neurons in adult mice led to a gradual decrease in the number of granule cells in the olfactory bulb, inhibition of increases in the granule cell number in the dentate gyrus and impairment of behaviors in contextual and spatial memory, which are known to depend on hippocampus. These results suggest that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory.}, author = {Imayoshi, Itaru and Sakamoto, Masayuki and Ohtsuka, Toshiyuki and Takao, Keizo and Miyakawa, Tsuyoshi and Yamaguchi, Masahiro and Mori, Kensaku and Ikeda, Toshio and Itohara, Shigeyoshi and Kageyama, Ryoichiro}, citeulike-article-id = {3343389}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn.2185}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn.2185}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18758458}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18758458}, day = {31}, doi = {10.1038/nn.2185}, issn = {1097-6256}, journal = {Nature Neuroscience}, keywords = {f1000, neurogenesis}, month = {August}, number = {10}, pages = {1153--1161}, posted-at = {2009-06-23 17:09:21}, priority = {4}, publisher = {Nature Publishing Group}, title = {Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain}, url = {http://dx.doi.org/10.1038/nn.2185}, volume = {11}, year = {2008} }

TY - JOUR ID - citeulike:3343389 L3 - citeulike-article-id:3343389 N2 - Neurogenesis occurs continuously in the forebrain of adult mammals, but the functional importance of adult neurogenesis is still unclear. Here, using a genetic labeling method in adult mice, we found that continuous neurogenesis results in the replacement of the majority of granule neurons in the olfactory bulb and a substantial addition of granule neurons to the hippocampal dentate gyrus. Genetic ablation of newly formed neurons in adult mice led to a gradual decrease in the number of granule cells in the olfactory bulb, inhibition of increases in the granule cell number in the dentate gyrus and impairment of behaviors in contextual and spatial memory, which are known to depend on hippocampus. These results suggest that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory. IS - 10 JF - Nature Neuroscience SN - 1097-6256 EP - 1161 TI - Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain PB - Nature Publishing Group VL - 11 SP - 1153 KW - f1000 KW - neurogenesis AU - Imayoshi, Itaru AU - Sakamoto, Masayuki AU - Ohtsuka, Toshiyuki AU - Takao, Keizo AU - Miyakawa, Tsuyoshi AU - Yamaguchi, Masahiro AU - Mori, Kensaku AU - Ikeda, Toshio AU - Itohara, Shigeyoshi AU - Kageyama, Ryoichiro PY - 2008/08/31/ UR - http://dx.doi.org/10.1038/nn.2185 ER -