Use-Dependent Plasticity in Clock Neurons Regulates Sleep Need in Drosophila Export

@article{citeulike:4269821, abstract = {Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry is uniquely positioned to coordinate interactions between processes underlying memory and sleep need. Flies increase sleep both after exposure to an enriched social environment and after protocols that induce long-term memory. We found that flies mutant for rutabaga, period, and blistered were deficient for experience-dependent increases in sleep. Rescue of each of these genes within the ventral lateral neurons (LNVs) restores increased sleep after social enrichment. Social experiences that induce increased sleep were associated with an increase in the number of synaptic terminals in the LNV projections into the medulla. The number of synaptic terminals was reduced during sleep and this decline was prevented by sleep deprivation. 10.1126/science.1166657}, author = {Donlea, Jeffrey M. and Ramanan, Narendrakumar and Shaw, Paul J.}, citeulike-article-id = {4269821}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1166657}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/324/5923/105}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19342592}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19342592}, day = {3}, doi = {10.1126/science.1166657}, journal = {Science}, keywords = {circadian, f1000, sleep, synapse}, month = {April}, number = {5923}, pages = {105--108}, posted-at = {2009-06-22 20:53:24}, priority = {2}, title = {Use-Dependent Plasticity in Clock Neurons Regulates Sleep Need in Drosophila}, url = {http://dx.doi.org/10.1126/science.1166657}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4269821 L3 - citeulike-article-id:4269821 N2 - Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry is uniquely positioned to coordinate interactions between processes underlying memory and sleep need. Flies increase sleep both after exposure to an enriched social environment and after protocols that induce long-term memory. We found that flies mutant for rutabaga, period, and blistered were deficient for experience-dependent increases in sleep. Rescue of each of these genes within the ventral lateral neurons (LNVs) restores increased sleep after social enrichment. Social experiences that induce increased sleep were associated with an increase in the number of synaptic terminals in the LNV projections into the medulla. The number of synaptic terminals was reduced during sleep and this decline was prevented by sleep deprivation. 10.1126/science.1166657 IS - 5923 JF - Science EP - 108 TI - Use-Dependent Plasticity in Clock Neurons Regulates Sleep Need in Drosophila VL - 324 SP - 105 KW - circadian KW - f1000 KW - sleep KW - synapse AU - Donlea, Jeffrey AU - Ramanan, Narendrakumar AU - Shaw, Paul PY - 2009/04/03/ UR - http://dx.doi.org/10.1126/science.1166657 ER -