Driving fast-spiking cells induces gamma rhythm and controls sensory responses Export

@article{citeulike:4408665, abstract = {Cortical gamma oscillations (20-80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Current theory predicts that gamma oscillations are generated by synchronous activity of fast-spiking inhibitory interneurons, with the resulting rhythmic inhibition producing neural ensemble synchrony by generating a narrow window for effective excitation. We causally tested these hypotheses in barrel cortex in vivo by targeting optogenetic manipulation selectively to fast-spiking interneurons. Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8-200 Hz) selectively amplifies gamma oscillations. In contrast, pyramidal neuron activation amplifies only lower frequency oscillations, a cell-type-specific double dissociation. We found that the timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses. Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.}, author = {Cardin, Jessica A. and Carlen, Marie and Meletis, Konstantinos and Knoblich, Ulf and Zhang, Feng and Deisseroth, Karl and Tsai, Li-Huei and Moore, Christopher I.}, citeulike-article-id = {4408665}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature08002}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature08002}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19396156}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19396156}, day = {26}, doi = {10.1038/nature08002}, issn = {0028-0836}, journal = {Nature}, keywords = {f1000, gamma, parvalbumin}, month = {April}, number = {7247}, pages = {663--667}, posted-at = {2009-06-23 16:33:41}, priority = {4}, publisher = {Nature Publishing Group}, title = {Driving fast-spiking cells induces gamma rhythm and controls sensory responses}, url = {http://dx.doi.org/10.1038/nature08002}, volume = {459}, year = {2009} }

TY - JOUR ID - citeulike:4408665 L3 - citeulike-article-id:4408665 N2 - Cortical gamma oscillations (20-80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Current theory predicts that gamma oscillations are generated by synchronous activity of fast-spiking inhibitory interneurons, with the resulting rhythmic inhibition producing neural ensemble synchrony by generating a narrow window for effective excitation. We causally tested these hypotheses in barrel cortex in vivo by targeting optogenetic manipulation selectively to fast-spiking interneurons. Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8-200 Hz) selectively amplifies gamma oscillations. In contrast, pyramidal neuron activation amplifies only lower frequency oscillations, a cell-type-specific double dissociation. We found that the timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses. Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation. IS - 7247 JF - Nature SN - 0028-0836 EP - 667 TI - Driving fast-spiking cells induces gamma rhythm and controls sensory responses PB - Nature Publishing Group VL - 459 SP - 663 KW - f1000 KW - gamma KW - parvalbumin AU - Cardin, Jessica AU - Carlen, Marie AU - Meletis, Konstantinos AU - Knoblich, Ulf AU - Zhang, Feng AU - Deisseroth, Karl AU - Tsai, Li-Huei AU - Moore, Christopher PY - 2009/04/26/ UR - http://dx.doi.org/10.1038/nature08002 ER -