Adverse effects of chronic circadian desynchronization in animals in a "challenging" environment. Export

@article{citeulike:4934096, abstract = {Continuous disruption of circadian rhythms, as seen in human shift workers, has been associated with the development of a number of adverse mental and physiological conditions. However, scientific evidence linking circadian disruption to overall health, particularly in animal models, is not well documented. In this study, we have demonstrated that exposing C57BL/6J mice to 12-h phase shifts every 5 days for 3 mo had no effect on body weight or intestinal physiology. However, when animals were further challenged with dextran sodium sulfate to induce colitis, chronic shifting of the light-dark cycle led to a dramatic increase in the progression of the colitis as indicated by reduced body weight, abnormal intestinal histopathology, and an exacerbated inflammatory response. These data indicate that circadian disruption is an important predisposing factor that may provoke the onset or worsening of various disease states such as inflammatory disorders. This study provides further evidence for continued investigations using animal models of circadian disruption to examine the consequences of circadian disruption on health when organisms are faced with a "challenging" environment.}, author = {Preuss, F. and Tang, Y. and Laposky, A. D. and Arble, D. and Keshavarzian, A. and Turek, F. W.}, citeulike-article-id = {4934096}, citeulike-linkout-0 = {http://dx.doi.org/10.1152/ajpregu.00118.2008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18843092}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18843092}, doi = {10.1152/ajpregu.00118.2008}, issn = {0363-6119}, journal = {American journal of physiology. Regulatory, integrative and comparative physiology}, keywords = {circadian, f1000, sleep}, month = {December}, number = {6}, posted-at = {2009-06-23 15:22:01}, priority = {2}, title = {Adverse effects of chronic circadian desynchronization in animals in a "challenging" environment.}, url = {http://dx.doi.org/10.1152/ajpregu.00118.2008}, volume = {295}, year = {2008} }

TY - JOUR ID - citeulike:4934096 L3 - citeulike-article-id:4934096 N2 - Continuous disruption of circadian rhythms, as seen in human shift workers, has been associated with the development of a number of adverse mental and physiological conditions. However, scientific evidence linking circadian disruption to overall health, particularly in animal models, is not well documented. In this study, we have demonstrated that exposing C57BL/6J mice to 12-h phase shifts every 5 days for 3 mo had no effect on body weight or intestinal physiology. However, when animals were further challenged with dextran sodium sulfate to induce colitis, chronic shifting of the light-dark cycle led to a dramatic increase in the progression of the colitis as indicated by reduced body weight, abnormal intestinal histopathology, and an exacerbated inflammatory response. These data indicate that circadian disruption is an important predisposing factor that may provoke the onset or worsening of various disease states such as inflammatory disorders. This study provides further evidence for continued investigations using animal models of circadian disruption to examine the consequences of circadian disruption on health when organisms are faced with a "challenging" environment. IS - 6 JF - American journal of physiology. Regulatory, integrative and comparative physiology SN - 0363-6119 TI - Adverse effects of chronic circadian desynchronization in animals in a "challenging" environment. VL - 295 KW - circadian KW - f1000 KW - sleep AU - Preuss, F AU - Tang, Y AU - Laposky, AD AU - Arble, D AU - Keshavarzian, A AU - Turek, FW PY - 2008/12// UR - http://dx.doi.org/10.1152/ajpregu.00118.2008 ER -