Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Export

@article{citeulike:790991, abstract = {Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment.}, address = {Department of Biology, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA.}, author = {Weisstaub, N. V. and Zhou, M. and Lira, A. and Lambe, E. and Gonz\'{a}lez-Maeso, J. and Hornung, J. P. and Sibille, E. and Underwood, M. and Itohara, S. and Dauer, W. T. and Ansorge, M. S. and Morelli, E. and Mann, J. J. and Toth, M. and Aghajanian, G. and Sealfon, S. C. and Hen, R. and Gingrich, J. A.}, citeulike-article-id = {790991}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1123432}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16873667}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16873667}, comment = {Using conditional mutagenesis, the authors provide direct evidence for the involvement of cortical 5HT2A receptors in the regulation of anxiety-like behavior. These findings suggest new uses of drugs aimed at this receptor in the treatment of anxiety disorders. Evaluated 8 Aug 2006}, day = {28}, doi = {10.1126/science.1123432}, issn = {1095-9203}, journal = {Science}, keywords = {5ht2a, anxiety, f1000, receptor}, month = {July}, number = {5786}, pages = {536--540}, posted-at = {2006-08-09 16:33:33}, priority = {2}, title = {Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.}, url = {http://dx.doi.org/10.1126/science.1123432}, volume = {313}, year = {2006} }

TY - JOUR ID - citeulike:790991 L3 - citeulike-article-id:790991 N2 - Serotonin [5-hydroxytryptamine (5-HT)] neurotransmission in the central nervous system modulates depression and anxiety-related behaviors in humans and rodents, but the responsible downstream receptors remain poorly understood. We demonstrate that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors. Selective restoration of 5HT2AR signaling to the cortex normalized conflict anxiety behaviors. These findings indicate a specific role for cortical 5HT2AR function in the modulation of conflict anxiety, consistent with models of cortical, "top-down" influences on risk assessment. IS - 5786 JF - Science SN - 1095-9203 AD - Department of Biology, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA. EP - 540 TI - Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. VL - 313 SP - 536 KW - 5ht2a KW - anxiety KW - f1000 KW - receptor N1 - Using conditional mutagenesis, the authors provide direct evidence for the involvement of cortical 5HT2A receptors in the regulation of anxiety-like behavior. These findings suggest new uses of drugs aimed at this receptor in the treatment of anxiety disorders. Evaluated 8 Aug 2006 AU - Weisstaub, NV AU - Zhou, M AU - Lira, A AU - Lambe, E AU - González-Maeso, J AU - Hornung, JP AU - Sibille, E AU - Underwood, M AU - Itohara, S AU - Dauer, WT AU - Ansorge, MS AU - Morelli, E AU - Mann, JJ AU - Toth, M AU - Aghajanian, G AU - Sealfon, SC AU - Hen, R AU - Gingrich, JA PY - 2006/07/28/ UR - http://dx.doi.org/10.1126/science.1123432 ER -