Sleep and brain monoamine changes produced by acute and chronic acetaldehyde administration in rats. Export

@article{citeulike:813990, abstract = {Acetaldehyde, the most toxic metabolite of ethanol, has been implicated in many toxic effects of ethanol. In the present study, we used rats to investigate the possible changes on the sleep-wake cycle and brain regional concentrations of noradrenaline and serotonin after intraperitoneal administration of several doses of acetaldehyde. Results showed that acetaldehyde significantly decreases the time spent in rapid eye movements sleep and wakefulness and increases the time spent in slow-wave sleep. The neurochemical analysis showed that acetaldehyde significantly increases the 5-hydroxyindolacetic acid content and 5-hydroxyindolacetic acid/serotonin ratio at the bulb and pons. These results suggest that acetaldehyde modifies the metabolism of serotonin which has been implicated in the onset and sustaining of the sleep episodes occurring along the sleep-wake cycle.}, address = {Departamento de Neurofisiolog\'{\i}a, Instituto Nacional de Neurolog\'{\i}a y Neurocirug\'{\i}a, ” Manuel Velasco Su\'{a}rez”, Insurgentes Sur No. 3877, Col. La Fama, C.P. 14269 M\'{e}xico, D.F., M\'{e}xico.}, author = {Franco-P\'{e}rez, Javier and Padilla, M\'{o}nica and Paz, Carlos}, citeulike-article-id = {813990}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbr.2006.07.008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16920203}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16920203}, comment = {Departamento de Neurofisiologia, Instituto Nacional de Neurologia y Neurocirugia, "Manuel Velasco Suarez", Insurgentes Sur No. 3877, Col. La Fama, C.P. 14269 Mexico, D.F., Mexico. Acetaldehyde, the most toxic metabolite of ethanol, has been implicated in many toxic effects of ethanol. In the present study, we used rats to investigate the possible changes on the sleep-wake cycle and brain regional concentrations of noradrenaline and serotonin after intraperitoneal administration of several doses of acetaldehyde. Results showed that acetaldehyde significantly decreases the time spent in rapid eye movements sleep and wakefulness and increases the time spent in slow-wave sleep. The neurochemical analysis showed that acetaldehyde significantly increases the 5-hydroxyindolacetic acid content and 5-hydroxyindolacetic acid/serotonin ratio at the bulb and pons. These results suggest that acetaldehyde modifies the metabolism of serotonin which has been implicated in the onset and sustaining of the sleep episodes occurring along the sleep-wake cycle.}, day = {17}, doi = {10.1016/j.bbr.2006.07.008}, issn = {0166-4328}, journal = {Behav Brain Res}, keywords = {5-ht, alcohol, rat, serotonin, sleep}, month = {August}, posted-at = {2006-08-23 21:12:33}, priority = {2}, title = {Sleep and brain monoamine changes produced by acute and chronic acetaldehyde administration in rats.}, url = {http://dx.doi.org/10.1016/j.bbr.2006.07.008}, year = {2006} }

TY - JOUR ID - citeulike:813990 L3 - citeulike-article-id:813990 N2 - Acetaldehyde, the most toxic metabolite of ethanol, has been implicated in many toxic effects of ethanol. In the present study, we used rats to investigate the possible changes on the sleep-wake cycle and brain regional concentrations of noradrenaline and serotonin after intraperitoneal administration of several doses of acetaldehyde. Results showed that acetaldehyde significantly decreases the time spent in rapid eye movements sleep and wakefulness and increases the time spent in slow-wave sleep. The neurochemical analysis showed that acetaldehyde significantly increases the 5-hydroxyindolacetic acid content and 5-hydroxyindolacetic acid/serotonin ratio at the bulb and pons. These results suggest that acetaldehyde modifies the metabolism of serotonin which has been implicated in the onset and sustaining of the sleep episodes occurring along the sleep-wake cycle. JF - Behav Brain Res SN - 0166-4328 AD - Departamento de Neurofisiología, Instituto Nacional de Neurología y Neurocirugía, “Manuel Velasco Suárez”, Insurgentes Sur No. 3877, Col. La Fama, C.P. 14269 México, D.F., México. TI - Sleep and brain monoamine changes produced by acute and chronic acetaldehyde administration in rats. KW - 5-ht KW - alcohol KW - rat KW - serotonin KW - sleep N1 - Departamento de Neurofisiologia, Instituto Nacional de Neurologia y Neurocirugia, "Manuel Velasco Suarez", Insurgentes Sur No. 3877, Col. La Fama, C.P. 14269 Mexico, D.F., Mexico. Acetaldehyde, the most toxic metabolite of ethanol, has been implicated in many toxic effects of ethanol. In the present study, we used rats to investigate the possible changes on the sleep-wake cycle and brain regional concentrations of noradrenaline and serotonin after intraperitoneal administration of several doses of acetaldehyde. Results showed that acetaldehyde significantly decreases the time spent in rapid eye movements sleep and wakefulness and increases the time spent in slow-wave sleep. The neurochemical analysis showed that acetaldehyde significantly increases the 5-hydroxyindolacetic acid content and 5-hydroxyindolacetic acid/serotonin ratio at the bulb and pons. These results suggest that acetaldehyde modifies the metabolism of serotonin which has been implicated in the onset and sustaining of the sleep episodes occurring along the sleep-wake cycle. AU - Franco-Pérez, Javier AU - Padilla, Mónica AU - Paz, Carlos PY - 2006/08/17/ UR - http://dx.doi.org/10.1016/j.bbr.2006.07.008 ER -