Immunohistochemical screening for autoantibodies against lateral hypothalamic neurons in human narcolepsy. Export

@article{citeulike:832383, abstract = {Most human patients with narcolepsy have no detectable hypocretin-1 in their cerebrospinal fluid. The cause of this hypocretin deficiency is unknown, but the prevailing hypothesis states that an autoimmune-mediated mechanism is responsible. We screened for the presence of autoantibodies against neurons in the lateral hypothalamus in 76 patients and 63 controls, using immunohistochemistry. Autoantibodies were present in two patients, but also in two controls. However, one of the patients had a clearly different staining pattern and nerve endings of immunolabeled cells were found to project onto hypocretin-producing neurons, suggesting a possible pathophysiological role. Humoral immune mechanisms appear not to play a role in the pathogenesis of narcolepsy, at least not in the clinically overt stage of the disease.}, address = {Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands. S.Overeem@neuro.umcn.nl}, author = {Overeem, S. and Verschuuren, J. J. and Fronczek, R. and Schreurs, L. and den Hertog, H. and Hegeman-Kleinn, I. M. and van Duinen, S. G. and Unmehopa, U. A. and Swaab, D. F. and Lammers, G. J.}, citeulike-article-id = {832383}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jneuroim.2006.02.010}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16563524}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16563524}, doi = {10.1016/j.jneuroim.2006.02.010}, issn = {0165-5728}, journal = {J Neuroimmunol}, keywords = {autoimmune, human, orexin}, month = {May}, number = {1-2}, pages = {187--191}, posted-at = {2006-09-06 13:56:38}, priority = {2}, title = {Immunohistochemical screening for autoantibodies against lateral hypothalamic neurons in human narcolepsy.}, url = {http://dx.doi.org/10.1016/j.jneuroim.2006.02.010}, volume = {174}, year = {2006} }

TY - JOUR ID - citeulike:832383 L3 - citeulike-article-id:832383 N2 - Most human patients with narcolepsy have no detectable hypocretin-1 in their cerebrospinal fluid. The cause of this hypocretin deficiency is unknown, but the prevailing hypothesis states that an autoimmune-mediated mechanism is responsible. We screened for the presence of autoantibodies against neurons in the lateral hypothalamus in 76 patients and 63 controls, using immunohistochemistry. Autoantibodies were present in two patients, but also in two controls. However, one of the patients had a clearly different staining pattern and nerve endings of immunolabeled cells were found to project onto hypocretin-producing neurons, suggesting a possible pathophysiological role. Humoral immune mechanisms appear not to play a role in the pathogenesis of narcolepsy, at least not in the clinically overt stage of the disease. IS - 1-2 JF - J Neuroimmunol SN - 0165-5728 AD - Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands. S.Overeem@neuro.umcn.nl EP - 191 TI - Immunohistochemical screening for autoantibodies against lateral hypothalamic neurons in human narcolepsy. VL - 174 SP - 187 KW - autoimmune KW - human KW - orexin AU - Overeem, S AU - Verschuuren, JJ AU - Fronczek, R AU - Schreurs, L AU - den Hertog, H AU - Hegeman-Kleinn, IM AU - van Duinen, SG AU - Unmehopa, UA AU - Swaab, DF AU - Lammers, GJ PY - 2006/05// UR - http://dx.doi.org/10.1016/j.jneuroim.2006.02.010 ER -