Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala Export

@article{citeulike:873631, abstract = {Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task, we developed a protocol that allowed us to dissociate the generation and monitoring of emotional conflict from its resolution. Using functional magnetic resonance imaging (fMRI), we find that activity in the amygdala and dorsomedial and dorsolateral prefrontal cortices reflects the amount of emotional conflict. By contrast, the resolution of emotional conflict is associated with activation of the rostral anterior cingulate cortex. Activation of the rostral cingulate is predicted by the amount of previous-trial conflict-related neural activity and is accompanied by a simultaneous and correlated reduction of amygdalar activity. These data suggest that emotional conflict is resolved through top-down inhibition of amygdalar activity by the rostral cingulate cortex.}, address = {Center for Neurobiology and Behavior, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032; Kavli Institute for Brain Sciences, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032.}, author = {Etkin, Amit and Egner, Tobias and Peraza, Daniel M. and Kandel, Eric R. and Hirsch, Joy}, citeulike-article-id = {873631}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2006.07.029}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S089662730600626X}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16982430}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16982430}, day = {21}, doi = {10.1016/j.neuron.2006.07.029}, issn = {08966273}, journal = {Neuron}, keywords = {acc, amygdala, emotion}, month = {September}, number = {6}, pages = {871--882}, posted-at = {2006-09-26 17:16:39}, priority = {2}, title = {Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala}, url = {http://dx.doi.org/10.1016/j.neuron.2006.07.029}, volume = {51}, year = {2006} }

TY - JOUR ID - citeulike:873631 L3 - citeulike-article-id:873631 N2 - Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task, we developed a protocol that allowed us to dissociate the generation and monitoring of emotional conflict from its resolution. Using functional magnetic resonance imaging (fMRI), we find that activity in the amygdala and dorsomedial and dorsolateral prefrontal cortices reflects the amount of emotional conflict. By contrast, the resolution of emotional conflict is associated with activation of the rostral anterior cingulate cortex. Activation of the rostral cingulate is predicted by the amount of previous-trial conflict-related neural activity and is accompanied by a simultaneous and correlated reduction of amygdalar activity. These data suggest that emotional conflict is resolved through top-down inhibition of amygdalar activity by the rostral cingulate cortex. IS - 6 JF - Neuron SN - 08966273 AD - Center for Neurobiology and Behavior, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032; Kavli Institute for Brain Sciences, Columbia University Medical Center, Neurological Institute Box 108, 710 West 168th Street, New York, New York 10032. EP - 882 TI - Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala VL - 51 SP - 871 KW - acc KW - amygdala KW - emotion AU - Etkin, Amit AU - Egner, Tobias AU - Peraza, Daniel AU - Kandel, Eric AU - Hirsch, Joy PY - 2006/09/21/ UR - http://dx.doi.org/10.1016/j.neuron.2006.07.029 ER -