Dietary Prenatal Choline Supplementation Alters Postnatal Hippocampal Structure and Function

@article{citeulike:892674, abstract = {Choline, a compound present in many foods, has recently been classified as an essential nutrient for humans. Studies with animal models indicate that the availability of choline during the prenatal period influences neural and cognitive development. Specifically, prenatal choline supplementation has been shown to enhance working memory and hippocampal long-term potentiation (LTP) in adult offspring. However, the cellular mechanisms underlying these effects remain unclear. Here we report that choline supplementation, during a 6-day gestational period, results in greater excitatory responsiveness, reduced slow afterhyperpolarizations (sAHPs), enhanced afterdepolarizing potentials (ADPs), larger somata, and greater basal dendritic arborization among hippocampal CA1 pyramidal cells studied postnatally in juvenile rats (20-25 days of age). These data indicate that dietary supplementation with a single nutrient, choline, during a brief, critical period of prenatal development, alters the structure and function of hippocampal pyramidal cells. 10.1152/jn.00785.2003}, author = {Li, Qiang and Guo-Ross, Shirley and Lewis, Darrell V. and Turner, Dennis and White, Aaron M. and Wilson, Wilkie A. and Swartzwelder, Scott H. }, citeulike-article-id = {892674}, doi = {http://dx.doi.org/10.1152/jn.00785.2003}, journal = {J Neurophysiol}, keywords = {ach, choline, hippocampus, postnatal}, month = {April}, number = {4}, pages = {1545--1555}, posted-at = {2006-10-11 12:38:47}, priority = {2}, title = {Dietary Prenatal Choline Supplementation Alters Postnatal Hippocampal Structure and Function}, url = {http://dx.doi.org/10.1152/jn.00785.2003}, volume = {91}, year = {2004} }

TY - JOUR ID - citeulike:892674 L3 - citeulike-article-id:892674 TI - Dietary Prenatal Choline Supplementation Alters Postnatal Hippocampal Structure and Function JF - J Neurophysiol VL - 91 IS - 4 SP - 1545 EP - 1555 N2 - Choline, a compound present in many foods, has recently been classified as an essential nutrient for humans. Studies with animal models indicate that the availability of choline during the prenatal period influences neural and cognitive development. Specifically, prenatal choline supplementation has been shown to enhance working memory and hippocampal long-term potentiation (LTP) in adult offspring. However, the cellular mechanisms underlying these effects remain unclear. Here we report that choline supplementation, during a 6-day gestational period, results in greater excitatory responsiveness, reduced slow afterhyperpolarizations (sAHPs), enhanced afterdepolarizing potentials (ADPs), larger somata, and greater basal dendritic arborization among hippocampal CA1 pyramidal cells studied postnatally in juvenile rats (20-25 days of age). These data indicate that dietary supplementation with a single nutrient, choline, during a brief, critical period of prenatal development, alters the structure and function of hippocampal pyramidal cells. 10.1152/jn.00785.2003 KW - ach KW - choline KW - hippocampus KW - postnatal AU - Li, Qiang AU - Guo-Ross, Shirley AU - Lewis, Darrell AU - Turner, Dennis AU - White, Aaron AU - Wilson, Wilkie AU - Swartzwelder, Scott PY - 2004/04/01/ UR - http://dx.doi.org/10.1152/jn.00785.2003 ER -