Evidence for a Ca2+ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum. Export

@article{citeulike:4365673, abstract = {The solubilized [3H]ryanodine receptor from cardiac sarcoplasmic reticulum was centrifuged through linear sucrose gradients. A single peak of radioactivity with apparent sedimentation coefficient of approximately 30S specifically comigrated with a high molecular weight protein of apparent relative molecular mass approximately 400,000. Incorporation of the ryanodine receptor into lipid bilayers induced single Ca2+ channel currents with conductance and kinetic behavior almost identical to that of native cardiac Ca2+ release channels. These results suggest that the cardiac ryanodine receptor comprises the Ca2+ release channel involved in excitation-contraction coupling in cardiac muscle.}, author = {Lai, F. A. and Anderson, K. and Rousseau, E. and Liu, Q. Y. and Meissner, G.}, citeulike-article-id = {4365673}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/2450540}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=2450540}, day = {29}, issn = {0006-291X}, journal = {Biochemical and biophysical research communications}, keywords = {binding, calcium, cardiac, channel, protein, receptor, release, reticulum, ryanodine, sarcoplasmic, sr}, month = {February}, number = {1}, pages = {441--449}, posted-at = {2009-04-19 22:16:52}, priority = {2}, title = {Evidence for a Ca2+ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/2450540}, volume = {151}, year = {1988} }

TY - JOUR ID - citeulike:4365673 L3 - citeulike-article-id:4365673 N2 - The solubilized [3H]ryanodine receptor from cardiac sarcoplasmic reticulum was centrifuged through linear sucrose gradients. A single peak of radioactivity with apparent sedimentation coefficient of approximately 30S specifically comigrated with a high molecular weight protein of apparent relative molecular mass approximately 400,000. Incorporation of the ryanodine receptor into lipid bilayers induced single Ca2+ channel currents with conductance and kinetic behavior almost identical to that of native cardiac Ca2+ release channels. These results suggest that the cardiac ryanodine receptor comprises the Ca2+ release channel involved in excitation-contraction coupling in cardiac muscle. IS - 1 JF - Biochemical and biophysical research communications SN - 0006-291X EP - 449 TI - Evidence for a Ca2+ channel within the ryanodine receptor complex from cardiac sarcoplasmic reticulum. VL - 151 SP - 441 KW - binding KW - calcium KW - cardiac KW - channel KW - protein KW - receptor KW - release KW - reticulum KW - ryanodine KW - sarcoplasmic KW - sr AU - Lai, FA AU - Anderson, K AU - Rousseau, E AU - Liu, QY AU - Meissner, G PY - 1988/02/29/ UR - http://view.ncbi.nlm.nih.gov/pubmed/2450540 ER -