Aspects of the mechanism of action of local anesthetics on the sarcoplasmic reticulum of skeletal muscle. Export

@article{citeulike:5016493, abstract = {1. The effect was studied of local anesthetics (tetracaine, dibucaine, procaine and xylocaine) on the forward and the backward reactions of the calcium pump of skeletal muscle sarcoplasmic reticulum. 2. The inhibition of the rate of calcium uptake, the rate of calcium-dependent ATP splitting and the rate of calcium-dependent ATP-ADP phosphate exchange by sarcoplasmic reticulum in the presence of the above drugs is at least partially due to the inhibition of the phosphoprotein formation from ATP. 3. The rate of the ADP-induced calcium release from sarcoplasmic reticulum and the rate of ATP synthesis driven by the calcium efflux are inhibited on account of a reduction of the phosphoprotein formation by orthophosphate. 4. The phosphorylation of calcium transport ATPase by either ATP or orthophosphate is diminished by the local anesthetics owing to a reduction in the apparent calcium affinity of sarcoplasmic reticulum emmbranes on the outside and on the inside, respectively. 5. The drug-induced calcium efflux from calcium-preloaded sarcoplasmic reticulum vesicles, a reaction not requiring ADP, is probably not mediated by calcium transport ATPase.}, author = {Suko, J. and Winkler, F. and Scharinger, B. and Hellmann, G.}, citeulike-article-id = {5016493}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/134747}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=134747}, day = {7}, issn = {0006-3002}, journal = {Biochimica et biophysica acta}, keywords = {anaesthetic, local, muscle, procaine, reticulum, sarcoplasmic, skeletal, tetracaine}, month = {September}, number = {3}, pages = {571--586}, posted-at = {2009-06-30 00:19:12}, priority = {2}, title = {Aspects of the mechanism of action of local anesthetics on the sarcoplasmic reticulum of skeletal muscle.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/134747}, volume = {443}, year = {1976} }

TY - JOUR ID - citeulike:5016493 L3 - citeulike-article-id:5016493 N2 - 1. The effect was studied of local anesthetics (tetracaine, dibucaine, procaine and xylocaine) on the forward and the backward reactions of the calcium pump of skeletal muscle sarcoplasmic reticulum. 2. The inhibition of the rate of calcium uptake, the rate of calcium-dependent ATP splitting and the rate of calcium-dependent ATP-ADP phosphate exchange by sarcoplasmic reticulum in the presence of the above drugs is at least partially due to the inhibition of the phosphoprotein formation from ATP. 3. The rate of the ADP-induced calcium release from sarcoplasmic reticulum and the rate of ATP synthesis driven by the calcium efflux are inhibited on account of a reduction of the phosphoprotein formation by orthophosphate. 4. The phosphorylation of calcium transport ATPase by either ATP or orthophosphate is diminished by the local anesthetics owing to a reduction in the apparent calcium affinity of sarcoplasmic reticulum emmbranes on the outside and on the inside, respectively. 5. The drug-induced calcium efflux from calcium-preloaded sarcoplasmic reticulum vesicles, a reaction not requiring ADP, is probably not mediated by calcium transport ATPase. IS - 3 JF - Biochimica et biophysica acta SN - 0006-3002 EP - 586 TI - Aspects of the mechanism of action of local anesthetics on the sarcoplasmic reticulum of skeletal muscle. VL - 443 SP - 571 KW - anaesthetic KW - local KW - muscle KW - procaine KW - reticulum KW - sarcoplasmic KW - skeletal KW - tetracaine AU - Suko, J AU - Winkler, F AU - Scharinger, B AU - Hellmann, G PY - 1976/09/07/ UR - http://view.ncbi.nlm.nih.gov/pubmed/134747 ER -