The control of sarcoplasmic reticulum Ca content in cardiac muscle Export

@article{citeulike:5333698, abstract = {Most of the calcium that activates contraction in the heart comes from the sarcoplasmic reticulum (SR) and it is therefore essential to control the SR Ca content. SR Ca content reflects the balance between uptake (via the SR Ca-ATPase, SERCA) and release, largely via the ryanodine receptor (RyR). Unwanted changes of SR Ca are prevented because, for example, an increase of SR Ca content increases the amplitude of the systolic Ca transient and this, in turn, results in increased loss of Ca from and decreased Ca entry into the cell thereby restoring cell and SR Ca towards control levels. We discuss the parameters that affect the steady level of SR Ca and how these may change in heart failure. Finally, we discuss disordered Ca regulation with particular emphasis on the condition of alternans where successive heartbeats alternate in amplitude. This behaviour can be explained by excessive feedback gain in the processes controlling SR Ca.}, author = {Diaz, M. and Graham, H. and Oneill, S. and Trafford, A. and Eisner, D.}, citeulike-article-id = {5333698}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ceca.2005.06.017}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0143416005001041}, doi = {10.1016/j.ceca.2005.06.017}, issn = {01434160}, journal = {Cell Calcium}, keywords = {calcium, cardiac, reticulum, sarcoplasmic}, month = {September}, number = {3-4}, pages = {391--396}, posted-at = {2009-08-02 23:17:38}, priority = {2}, title = {The control of sarcoplasmic reticulum Ca content in cardiac muscle}, url = {http://dx.doi.org/10.1016/j.ceca.2005.06.017}, volume = {38}, year = {2005} }

TY - JOUR ID - citeulike:5333698 L3 - citeulike-article-id:5333698 N2 - Most of the calcium that activates contraction in the heart comes from the sarcoplasmic reticulum (SR) and it is therefore essential to control the SR Ca content. SR Ca content reflects the balance between uptake (via the SR Ca-ATPase, SERCA) and release, largely via the ryanodine receptor (RyR). Unwanted changes of SR Ca are prevented because, for example, an increase of SR Ca content increases the amplitude of the systolic Ca transient and this, in turn, results in increased loss of Ca from and decreased Ca entry into the cell thereby restoring cell and SR Ca towards control levels. We discuss the parameters that affect the steady level of SR Ca and how these may change in heart failure. Finally, we discuss disordered Ca regulation with particular emphasis on the condition of alternans where successive heartbeats alternate in amplitude. This behaviour can be explained by excessive feedback gain in the processes controlling SR Ca. IS - 3-4 JF - Cell Calcium SN - 01434160 EP - 396 TI - The control of sarcoplasmic reticulum Ca content in cardiac muscle VL - 38 SP - 391 KW - calcium KW - cardiac KW - reticulum KW - sarcoplasmic AU - Diaz, M AU - Graham, H AU - Oneill, S AU - Trafford, A AU - Eisner, D PY - 2005/09// UR - http://dx.doi.org/10.1016/j.ceca.2005.06.017 ER -