The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle. Export

@article{citeulike:5725717, abstract = {1. The calcium-sensitive photoprotein aequorin was micro-injected into cells of rat and cat ventricular muscles. The resulting light emission is a function of intracellular free calcium concentration ([Ca2+]i). The transient increases in [Ca2+]i that accompany contraction were monitored. 2. After an increase in muscle length, the developed tension increased immediately and then showed a slow increase over a period of minutes. The peak [Ca2+]i in each contraction was initially unchanged after an increase in muscle length but then showed a slow increase with a time course similar to that of the slow tension change. 3. As a consequence of these slow changes, the shape of the tension-length relation depends on the procedure used to determine it and this change in shape can be attributed to changes in activation. 4. Immediately after an increase in muscle length the calcium transient was abbreviated. 5. When a quick release was performed during a contraction, a short-lived increase in the [Ca2+]i was observed following the release. 6. The two previous observations can both be explained if the binding constant of troponin for calcium is a function of developed tension.}, author = {Allen, D. G. and Kurihara, S.}, citeulike-article-id = {5725717}, citeulike-linkout-0 = {http://jphysiol.highwire.org/content/327/1/79.abstract}, citeulike-linkout-1 = {http://jphysiol.highwire.org/content/327/1/79.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/7120151}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=7120151}, day = {1}, journal = {The Journal of Physiology}, keywords = {calcium, cardiac, intracellular, length, muscle, stretch, transient}, month = {January}, number = {1}, pages = {79--94}, posted-at = {2009-09-05 09:12:58}, priority = {2}, title = {The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle.}, url = {http://jphysiol.highwire.org/content/327/1/79.abstract}, volume = {327}, year = {1982} }

TY - JOUR ID - citeulike:5725717 L3 - citeulike-article-id:5725717 N2 - 1. The calcium-sensitive photoprotein aequorin was micro-injected into cells of rat and cat ventricular muscles. The resulting light emission is a function of intracellular free calcium concentration ([Ca2+]i). The transient increases in [Ca2+]i that accompany contraction were monitored. 2. After an increase in muscle length, the developed tension increased immediately and then showed a slow increase over a period of minutes. The peak [Ca2+]i in each contraction was initially unchanged after an increase in muscle length but then showed a slow increase with a time course similar to that of the slow tension change. 3. As a consequence of these slow changes, the shape of the tension-length relation depends on the procedure used to determine it and this change in shape can be attributed to changes in activation. 4. Immediately after an increase in muscle length the calcium transient was abbreviated. 5. When a quick release was performed during a contraction, a short-lived increase in the [Ca2+]i was observed following the release. 6. The two previous observations can both be explained if the binding constant of troponin for calcium is a function of developed tension. IS - 1 JF - The Journal of Physiology EP - 94 TI - The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle. VL - 327 SP - 79 KW - calcium KW - cardiac KW - intracellular KW - length KW - muscle KW - stretch KW - transient AU - Allen, DG AU - Kurihara, S PY - 1982/01/01/ UR - http://jphysiol.highwire.org/content/327/1/79.abstract ER -