Action potentials, afterpotentials, and arrhythmias. Export

@article{citeulike:774686, abstract = {Triggered activity must be added to spontaneous activity and to circus movement as a cause for extrasystoles and tachycardias of either atrial or ventricular origin. The activity of a triggerable focus requires phase 4 depolarization caused by an afterpotential; this distinguishes it from the activity seen in circus movement. A triggerable focus becomes rhythmically active only if driven at a critical rate or by a critically timed premature impulse; this distinguishes it from a focus of spontaneous or automatic activity. The ease of triggering a triggerable focus increases in the presence of catecholamines; triggerable foci in the atrium become quiescent when exposed to acetylcholine. At the present time, fibers within the coronary sinus provide the most persuasive example of triggered activity as a possible cause of arrhythmias of clinical significance. It is possible that the coupled extrasystoles of digitalis toxicity may be triggered; there is every reason to believe that further examples of triggered arrhythmias of possible clinical significance will be discovered.}, author = {Cranefield, P. F.}, citeulike-article-id = {774686}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/409566}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=409566}, issn = {0009-7330}, journal = {Circ Res}, keywords = {action, aftercontraction, afterdepolarisation, afterpotential, arrhythia, automaticity, calcium, current, inward, potential, review, spontaneous, transient, triggered}, month = {October}, number = {4}, pages = {415--423}, posted-at = {2007-04-01 02:20:22}, priority = {2}, title = {Action potentials, afterpotentials, and arrhythmias.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/409566}, volume = {41}, year = {1977} }

TY - JOUR ID - citeulike:774686 L3 - citeulike-article-id:774686 N2 - Triggered activity must be added to spontaneous activity and to circus movement as a cause for extrasystoles and tachycardias of either atrial or ventricular origin. The activity of a triggerable focus requires phase 4 depolarization caused by an afterpotential; this distinguishes it from the activity seen in circus movement. A triggerable focus becomes rhythmically active only if driven at a critical rate or by a critically timed premature impulse; this distinguishes it from a focus of spontaneous or automatic activity. The ease of triggering a triggerable focus increases in the presence of catecholamines; triggerable foci in the atrium become quiescent when exposed to acetylcholine. At the present time, fibers within the coronary sinus provide the most persuasive example of triggered activity as a possible cause of arrhythmias of clinical significance. It is possible that the coupled extrasystoles of digitalis toxicity may be triggered; there is every reason to believe that further examples of triggered arrhythmias of possible clinical significance will be discovered. IS - 4 JF - Circ Res SN - 0009-7330 EP - 423 TI - Action potentials, afterpotentials, and arrhythmias. VL - 41 SP - 415 KW - action KW - aftercontraction KW - afterdepolarisation KW - afterpotential KW - arrhythia KW - automaticity KW - calcium KW - current KW - inward KW - potential KW - review KW - spontaneous KW - transient KW - triggered AU - Cranefield, PF PY - 1977/10// UR - http://view.ncbi.nlm.nih.gov/pubmed/409566 ER -