Self-Organization of Dynein Motors Generates Meiotic Nuclear Oscillations Export

@article{Vogel_PLoSBiol09, abstract = {Meiotic nuclear oscillations in the fission yeast Schizosaccharomyces pombe are crucial for proper chromosome pairing and recombination. We report a mechanism of these oscillations on the basis of collective behavior of dynein motors linking the cell cortex and dynamic microtubules that extend from the spindle pole body in opposite directions. By combining quantitative live cell imaging and laser ablation with a theoretical description, we show that dynein dynamically redistributes in the cell in response to load forces, resulting in more dynein attached to the leading than to the trailing microtubules. The redistribution of motors introduces an asymmetry of motor forces pulling in opposite directions, leading to the generation of oscillations. Our work provides the first direct in vivo observation of self-organized dynamic dynein distributions, which, owing to the intrinsic motor properties, generate regular large-scale movements in the cell.}, author = {Vogel, Sven K. and Pavin, Nenad and Maghelli, Nicola and J\"{u}licher, Frank and Toli\'{c}-N{\o}rrelykke, Iva M.}, citeulike-article-id = {4462260}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pbio.1000087}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19385717}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19385717}, day = {21}, doi = {10.1371/journal.pbio.1000087}, journal = {PLoS Biol}, keywords = {experimental, meiosis, motor-protein, nuclear, oscillation, self\_organization, theory}, month = {April}, number = {4}, pages = {e1000087+}, posted-at = {2009-10-28 18:54:20}, priority = {2}, publisher = {Public Library of Science}, title = {Self-Organization of Dynein Motors Generates Meiotic Nuclear Oscillations}, url = {http://dx.doi.org/10.1371/journal.pbio.1000087}, volume = {7}, year = {2009} }

TY - JOUR ID - Vogel_PLoSBiol09 L3 - citeulike-article-id:4462260 N2 - Meiotic nuclear oscillations in the fission yeast Schizosaccharomyces pombe are crucial for proper chromosome pairing and recombination. We report a mechanism of these oscillations on the basis of collective behavior of dynein motors linking the cell cortex and dynamic microtubules that extend from the spindle pole body in opposite directions. By combining quantitative live cell imaging and laser ablation with a theoretical description, we show that dynein dynamically redistributes in the cell in response to load forces, resulting in more dynein attached to the leading than to the trailing microtubules. The redistribution of motors introduces an asymmetry of motor forces pulling in opposite directions, leading to the generation of oscillations. Our work provides the first direct in vivo observation of self-organized dynamic dynein distributions, which, owing to the intrinsic motor properties, generate regular large-scale movements in the cell. IS - 4 JF - PLoS Biol TI - Self-Organization of Dynein Motors Generates Meiotic Nuclear Oscillations PB - Public Library of Science VL - 7 SP - e1000087 KW - experimental KW - meiosis KW - motor-protein KW - nuclear KW - oscillation KW - self_organization KW - theory AU - Vogel, Sven AU - Pavin, Nenad AU - Maghelli, Nicola AU - Jülicher, Frank AU - Tolić-Nørrelykke, Iva PY - 2009/04/21/ UR - http://dx.doi.org/10.1371/journal.pbio.1000087 ER -