Structural Properties of Pore-Forming Oligomers of α-Synuclein Export

@article{Kim_JACS09, abstract = {Soluble oligomers are potent toxins in many neurodegenerative diseases, but little is known about the structure of soluble oligomers and their structure−toxicity relationship. Here we prepared on-pathway oligomers of the 140-residue protein α-synuclein, a key player in Parkinson's disease, at concentrations an order of magnitude higher than previously possible. The oligomers form ion channels with well-defined conductance states in a variety of membranes, and their β-structure differs from that of amyloid fibrils of α-synuclein.}, author = {Kim, Hai-Young and Cho, Min-Kyu and Kumar, Ashutosh and Maier, Elke and Siebenhaar, Carsten and Becker, Stefan and Fernandez, Claudio O. and Lashuel, Hilal A. and Benz, Roland and Lange, Adam and Zweckstetter, Markus}, citeulike-article-id = {6070983}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/ja9077599}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/ja9077599}, doi = {10.1021/ja9077599}, journal = {Journal of the American Chemical Society}, keywords = {alpha-synuclein, amyloid, experimental, parkinson, pore, structure, toxicity}, number = {0}, posted-at = {2009-11-04 18:53:20}, priority = {2}, title = {Structural Properties of Pore-Forming Oligomers of α-Synuclein}, url = {http://dx.doi.org/10.1021/ja9077599}, volume = {0}, year = {0000} }

TY - JOUR ID - Kim_JACS09 L3 - citeulike-article-id:6070983 N2 - Soluble oligomers are potent toxins in many neurodegenerative diseases, but little is known about the structure of soluble oligomers and their structure−toxicity relationship. Here we prepared on-pathway oligomers of the 140-residue protein α-synuclein, a key player in Parkinson’s disease, at concentrations an order of magnitude higher than previously possible. The oligomers form ion channels with well-defined conductance states in a variety of membranes, and their β-structure differs from that of amyloid fibrils of α-synuclein. IS - 0 JF - Journal of the American Chemical Society TI - Structural Properties of Pore-Forming Oligomers of α-Synuclein VL - 0 KW - alpha-synuclein KW - amyloid KW - experimental KW - parkinson KW - pore KW - structure KW - toxicity AU - Kim, Hai-Young AU - Cho, Min-Kyu AU - Kumar, Ashutosh AU - Maier, Elke AU - Siebenhaar, Carsten AU - Becker, Stefan AU - Fernandez, Claudio AU - Lashuel, Hilal AU - Benz, Roland AU - Lange, Adam AU - Zweckstetter, Markus PY - 2000/// UR - http://dx.doi.org/10.1021/ja9077599 ER -