Lateral compressibility of lipid mono- and bilayers. Theory of membrane permeability Export

@article{Nagle_BBA78, abstract = {The passive sodium permeability of pure lipid vesicles and dispersions has a large peak at the bilayer phase transition temperature. We discuss this anomaly in terms of density fluctuations, which can open up cavities in the headgroup region into which small ions can enter, and which may be large if bilayer conditions at the melting point are similar to those near the critical point which seems to exist in monolayers. We present two arguments, one thermodynamic and one microscopic, which suggest that the permeability is proportional to the lateral compressibility. We then calculate the lateral compressibility for two previously published theoretical models and compare the results with experiment.}, author = {Nagle, J. and Scottjr, H.}, citeulike-article-id = {6087786}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/0005-2736(78)90176-1}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/0005273678901761}, day = {02}, doi = {10.1016/0005-2736(78)90176-1}, issn = {00052736}, journal = {Biochimica et Biophysica Acta (BBA) - Biomembranes}, keywords = {compressibility, leakage, membrane, permeability, theory}, month = {November}, number = {2}, pages = {236--243}, posted-at = {2009-11-09 12:04:21}, priority = {2}, title = {Lateral compressibility of lipid mono- and bilayers. Theory of membrane permeability}, url = {http://dx.doi.org/10.1016/0005-2736(78)90176-1}, volume = {513}, year = {1978} }

TY - JOUR ID - Nagle_BBA78 L3 - citeulike-article-id:6087786 N2 - The passive sodium permeability of pure lipid vesicles and dispersions has a large peak at the bilayer phase transition temperature. We discuss this anomaly in terms of density fluctuations, which can open up cavities in the headgroup region into which small ions can enter, and which may be large if bilayer conditions at the melting point are similar to those near the critical point which seems to exist in monolayers. We present two arguments, one thermodynamic and one microscopic, which suggest that the permeability is proportional to the lateral compressibility. We then calculate the lateral compressibility for two previously published theoretical models and compare the results with experiment. IS - 2 JF - Biochimica et Biophysica Acta (BBA) - Biomembranes SN - 00052736 EP - 243 TI - Lateral compressibility of lipid mono- and bilayers. Theory of membrane permeability VL - 513 SP - 236 KW - compressibility KW - leakage KW - membrane KW - permeability KW - theory AU - Nagle, J AU - Scottjr, H PY - 1978/11/02/ UR - http://dx.doi.org/10.1016/0005-2736(78)90176-1 ER -