Elastic bond network model for protein unfolding mechanics. Export

@article{citeulike:2664874, abstract = {Recent advances in single molecule mechanics have made it possible to investigate the mechanical anisotropy of protein stability in great detail. A quantitative prediction of protein unfolding forces at experimental time scales has so far been difficult. Here, we present an elastically bonded network model to describe the mechanical unfolding forces of green fluorescent protein in eight different pulling directions. The combination of an elastic network and irreversible bond fracture kinetics offers a new concept to understand the determinants of mechanical protein stability.}, address = {Dana-Farber Cancer Institute and BCMP, Harvard Medical School, Boston, Massachusetts 02115, USA.}, author = {Dietz, H. and Rief, M.}, citeulike-article-id = {2664874}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/18352751}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=18352751}, day = {7}, issn = {0031-9007}, journal = {Physical review letters}, keywords = {protein-mechanics, theoretical}, month = {March}, number = {9}, posted-at = {2008-04-14 01:21:23}, priority = {0}, title = {Elastic bond network model for protein unfolding mechanics.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/18352751}, volume = {100}, year = {2008} }

TY - JOUR ID - citeulike:2664874 L3 - citeulike-article-id:2664874 N2 - Recent advances in single molecule mechanics have made it possible to investigate the mechanical anisotropy of protein stability in great detail. A quantitative prediction of protein unfolding forces at experimental time scales has so far been difficult. Here, we present an elastically bonded network model to describe the mechanical unfolding forces of green fluorescent protein in eight different pulling directions. The combination of an elastic network and irreversible bond fracture kinetics offers a new concept to understand the determinants of mechanical protein stability. IS - 9 JF - Physical review letters SN - 0031-9007 AD - Dana-Farber Cancer Institute and BCMP, Harvard Medical School, Boston, Massachusetts 02115, USA. TI - Elastic bond network model for protein unfolding mechanics. VL - 100 KW - protein-mechanics KW - theoretical AU - Dietz, H AU - Rief, M PY - 2008/03/07/ UR - http://view.ncbi.nlm.nih.gov/pubmed/18352751 ER -